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001440707 019__ $$a1282000904$$a1282599439$$a1283859141$$a1287778238$$a1292517805
001440707 020__ $$a9783030854997$$q(electronic bk.)
001440707 020__ $$a303085499X$$q(electronic bk.)
001440707 020__ $$z9783030854980
001440707 020__ $$z3030854981
001440707 0247_ $$a10.1007/978-3-030-85499-7$$2doi
001440707 035__ $$aSP(OCoLC)1281773200
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001440707 049__ $$aISEA
001440707 050_4 $$aQP517.C45$$bP53 2021
001440707 08204 $$a572/.64$$223
001440707 24500 $$aPharmacology of the WNT signaling system /$$cGunnar Schulte, Pawel Kozielewicz, editors.
001440707 264_1 $$aCham :$$bSpringer,$$c[2021]
001440707 264_4 $$c©2021
001440707 300__ $$a1 online resource :$$billustrations
001440707 336__ $$atext$$btxt$$2rdacontent
001440707 337__ $$acomputer$$bc$$2rdamedia
001440707 338__ $$aonline resource$$bcr$$2rdacarrier
001440707 347__ $$atext file
001440707 347__ $$bPDF
001440707 4901_ $$aHandbook of experimental pharmacology,$$x1865-0325 ;$$vvolume 269
001440707 504__ $$aIncludes bibliographical references.
001440707 5050_ $$aPharmacological thinking in WNT signaling -- Controlling WNT Signaling Specificity and implications for targeting WNTs pharmacologically -- WNTs on exosomes -- Strategies to target LRPs in WNT signaling -- Targeting the receptor tyrosine kinase ROR1 by small molecules -- Assessing WNT binding and Frizzled activation employing genetically encoded, biophysical sensors -- Disheveled proteins as crucial mediators of WNT signaling -- Destruction complex and regulation of CTNNB1 -- Strategies to therapeutically target WNT/PCP like signaling in disease -- Mining natural compounds to target WNT signaling -- from mushrooms to corals -- FZD7 as a therapeutic target in intestinal cancer -- Targeting oncogenic WNT signaling with WNT derived peptides -- Targeting WNT signaling in lung pathology -- The role of WNT signaling in osteoarthritis and the therapeutic potential of its pharmacological targeting -- WNT signaling in Alzheimers disease and other neurodegenerative disorders -- opportunities for therapy? -- Targeting WNT signaling as a risk.
001440707 506__ $$aAccess limited to authorized users.
001440707 520__ $$aThis book reflects the state of the art of our understanding of the WNT signaling system, which comprises a network of signaling pathways initiated by the secreted WNT lipoglycoproteins, which are crucial for embryonal development, stem cell regulation, tissue homeostasis and repair. Dysfunction of this evolutionarily conserved signaling system leads to many diseases including developmental disorders, diverse forms of cancer, fibrosis, neurodegenerative disease and many more. The WNT signaling system is built upon 19 mammalian, secreted WNT lipoglycoproteins that interact with a plethora of distinct receptors, such as the G protein-coupled receptors called Frizzleds (FZD1-10), LDL receptor-like proteins (LRP5/6), receptor tyrosine kinases (ROR1, 2, RYK and PTK7). In addition, WNT pathways are tightly regulated by many secreted and cell-intrinsic negative regulators, such as soluble FZD-related proteins (SFRPs), Dickkopfs (DKKs), WNT-inhibitory proteins, TIKI, RNF43 and more. Understanding the basic mechanism in terms of receptor-ligand interaction, receptor selectivity, signal initiation and desensitization remain poorly understood, even though substantial advances have been made the recent years. Due to the involvement of the WNT signaling system in human disease, it appears obvious to target diverse branches pharmacologically and therapeutically. However, given the complexity of the system and its importance for stem cell regulation and tissue maintenance, therapy comes with obvious risks for severe side effects. The field is addressing the challenge to identify suitable targets and selective compounds for therapy allowing disease-selective therapeutic effects and balancing unwanted side effects. This book summarizes the current understanding of the basic and applied pharmacology in the WNT signaling system and bridges disciplines such as pharmacology, physiology, neurosciences, oncology and drug development.
001440707 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed November 12, 2021).
001440707 650_0 $$aWnt pathway.
001440707 650_0 $$aWnt proteins.
001440707 650_0 $$aNeuropharmacology.
001440707 650_6 $$aProtéines Wnt.
001440707 650_6 $$aNeuropharmacologie.
001440707 655_7 $$aLlibres electrònics.$$2thub
001440707 655_0 $$aElectronic books.
001440707 7001_ $$aSchulte, Gunnar,$$eeditor.
001440707 7001_ $$aKozielewicz, Pawel,$$eeditor.
001440707 77608 $$iPrint version:$$tPharmacology of the WNT signaling system.$$dCham : Springer, [2021]$$z3030854981$$z9783030854980$$w(OCoLC)1261362744
001440707 830_0 $$aHandbook of experimental pharmacology ;$$vv. 269.$$x1865-0325
001440707 852__ $$bebk
001440707 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-85499-7$$zOnline Access$$91397441.1
001440707 909CO $$ooai:library.usi.edu:1440707$$pGLOBAL_SET
001440707 980__ $$aBIB
001440707 980__ $$aEBOOK
001440707 982__ $$aEbook
001440707 983__ $$aOnline
001440707 994__ $$a92$$bISE