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Title
Circadian clock in brain health and disease / Olivia Engmann, Marco Brancaccio, editors.
ISBN
9783030811471 (electronic bk.)
3030811476 (electronic bk.)
3030811468
9783030811464
Publication Details
Cham, Switzerland : Springer, 2021.
Language
English
Description
1 online resource
Item Number
10.1007/978-3-030-81147-1 doi
Call Number
RC386
Dewey Decimal Classification
612/.022
Summary
In this book, leading experts in the field review how circadian rhythms impact the brain. An essential function of mammalian life is the exploitation of the regularities provided by the 24-hour cycle of day and night. The development and evolution of circadian clock mechanisms have allowed us to optimally adapt our behavior and physiology to the external world. Not surprisingly, a growing body of evidence links the disruption of circadian rhythms by genetic, lifestyle and environmental factors to illnesses of the brain. In the first section of the book, readers will learn about the molecular and anatomic architecture of circadian function in mammals. The ways in which environmental disruptions and misalignments can influence such mechanisms and therefore impair brain function and health status are also addressed. In the second part, the focus shifts to those brain regions responsible for brain function and the body-wide regulation of circadian function. Amongst others, special attention is paid to the role of astrocytes and the brain's reward and hyprocretin / orexin systems. The book concludes with an extensive discussion on the consequences of circadian rhythm dysfunction. Several chapters present the latest findings on Attention Deficit Hyperactivity Disorder, schizophrenia, autism spectrum disorder, drug abuse and mood disorders. Written by auhorities in the field, the book provides a state-of-the-art review of the latest findings on circadian clocks in the brain and highlights their potentially far-reaching impacts on our health and well-being. As such, it is essential reading for all neuroscientists and clinicians seeking to understand the intricate connections between circadian rhythms and brain health and illness.
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Access limited to authorized users.
Digital File Characteristics
text file
PDF
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed November 17, 2021).
Series
Advances in experimental medicine and biology ; v. 1344. 2214-8019
PART I. Molecular Gears of the Circadian Clock
Introduction to the Clock System
Circadian Clocks, Sleep, and Metabolism
Linking Depression to Epigenetics: Role of the Circadian Clock
PART II. Brain Regions Implicated in Circadian Rhythms
The Brain's Reward System in Health and Disease
Brain Clocks, Sleep and Mood
Astrocyte Circadian Timekeeping in Brain Health and Neurodegeneration
PART III. Clock and Mental Illness
The Role of the Circadian System in Attention Deficit Hyperactivity Disorder
How Psychoactive Drugs and the Circadian Clock Are Enlightening One Another
Circadian Rhythms in Mood Disorders
The Reciprocal Interaction Between Sleep and Alzheimer's Disease.
