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001441154 001__ 1441154
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001441154 005__ 20230309004722.0
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001441154 019__ $$a1286956955$$a1287049671$$a1287135565$$a1292518300$$a1294355546
001441154 020__ $$a9783030860165$$q(electronic bk.)
001441154 020__ $$a3030860167$$q(electronic bk.)
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001441154 0247_ $$a10.1007/978-3-030-86016-5$$2doi
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001441154 24500 $$aBone marrow niche :$$bmicroenvironments critical for immune cell development /$$cTakashi Nagasawa, editor.
001441154 260__ $$aCham, Switzerland :$$bSpringer,$$c2021.
001441154 300__ $$a1 online resource
001441154 336__ $$atext$$btxt$$2rdacontent
001441154 337__ $$acomputer$$bc$$2rdamedia
001441154 338__ $$aonline resource$$bcr$$2rdacarrier
001441154 347__ $$atext file
001441154 347__ $$bPDF
001441154 4901_ $$aCurrent topics in microbiology and immunology ;$$vv. 434
001441154 5050_ $$aPreface -- Skeletal stem cells as the developmental origin of cellular niches for hematopoietic stem and progenitor cells -- Cellular niches for hematopoietic stem cells and lympho-hematopoiesis in bone marrow during homeostasis and blood cancers -- Remodeling of the bone marrow stromal microenvironment during pathogenic infections -- The Roles of IL-7 and IL-15 in Niches for Lymphocyte Progenitors and Immune Cells in Lymphoid Organs -- Lymph node stromal cells: diverse meshwork structures weave functionally subdivided niches -- Immune Niche within the Peritoneal Cavity.
001441154 506__ $$aAccess limited to authorized users.
001441154 520__ $$aThis volume summarizes recent advances in research on mesenchymal cell populations in the bone marrow. It explores how mesenchymal cells create niches for immune cells in extramedullary organs and it discusses new concepts of lympho-hematopoietic microenvironments. Readers are introduced to the fundamentals of hematopoietic stem cells (HSCs) differentiation to all types of blood cells, including immune cells, in the bone marrow. The book highlights how this process is supported and regulated by the individual microenvironments of stem cells, termed niches. The identity of HSC niches has been subject to longstanding debates. Recent studies identified the population of mesenchymal stem cells as the major cellular component of niches, for hematopoietic stem and progenitor cells (HSPCs) and their candidate developmental origin. Furthermore, candidate cellular niches for immune cells in lymph nodes and adipose and connective tissues were identified. The authors of this volume focus on shared features between those and HSPC niche cells in the bone marrow. Covering latest research results, this book serves as fascinating read for researchers and clinicians in hematology and immunology.
001441154 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed December 17, 2021).
001441154 650_0 $$aBone marrow.
001441154 650_0 $$aStem cells.
001441154 650_6 $$aMoelle osseuse.
001441154 650_6 $$aCellules souches.
001441154 655_0 $$aElectronic books.
001441154 7001_ $$aNagasawa, Takashi,$$eeditor.
001441154 77608 $$iPrint version:$$tBone marrow niche.$$dCham, Switzerland : Springer, 2021$$z3030860159$$z9783030860158$$w(OCoLC)1262964935
001441154 830_0 $$aCurrent topics in microbiology and immunology ;$$vv. 434.
001441154 852__ $$bebk
001441154 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-86016-5$$zOnline Access$$91397441.1
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