@article{1443041,
      recid = {1443041},
      author = {Çakatay, Ufuk,},
      title = {Redox signaling and biomarkers in ageing /},
      publisher = {Springer,},
      address = {Cham, Switzerland :},
      pages = {1 online resource},
      year = {2022},
      abstract = {This book aims to present the age-related alterations in  redox signaling networks and their diagnostic biomarkers in  aging cells using multidisciplinary approach. Establishing  sensitive and specific biomarkers of dynamic redox  homeostasis is crucially important in the development of  effective antiaging and senolytic interventions. Recent  years have seen tremendous advances in the understanding of  redox signaling events which highlight the process of aging  and age-related pathologies. A major challenge in  biological aging research is developing reliable biomarkers  to determine the consequences of disrupted redox signaling  networks long before the clinical diagnosis of age-related  diseases is made. Therefore, we have chosen to concentrate  on aging-induced aberrant redox signaling networks, their  biomarkers, and pathological consequences in this book.  Although oxidation is a natural metabolic process, the  imbalance in the level of oxidants and antioxidants causes  oxidative stress and eventually leads to inflammatory  conditions, diabetes, neurodegenerative diseases, and  cancer. Novel redox-sensitive biomarkers for the evaluation  of aging-induced proteinopathies such as amyloid and tau  proteins in Alzheimer's disease, [alpha]-synuclein in  Parkinson's disease, and islet amyloid polypeptides in type  2 diabetes mellitus recently drew the attention of  researchers. Inside this textbook, readers will find  comprehensive perspectives on the association between redox  homeostasis and the aging process both at the molecular and  clinical levels. Due to the inherent relationship between  impaired metabolic activities and oxidative stress, the  temporal interaction between intermediary metabolism and  disturbed redox status can lead to greater susceptibility  to aging-induced diseases and disorders, such as  cardiovascular diseases, hypertension, and diabetes. This  knowledge could be a key to continued research toward  improving medication regimens such as in cancer and  cardiovascular therapies, and procedural outcomes for  patients. This book brings together current research  evidence and knowledge on redox signaling and biomarkers in  aging in chapters written by leading global experts in this  rapidly evolving field. We hope that this textbook is of  interest to a wide group of researchers, advanced students,  scientifically curious non-specialist readers and  clinicians alike.},
      url = {http://library.usi.edu/record/1443041},
      doi = {https://doi.org/10.1007/978-3-030-84965-8},
}