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001443540 001__ 1443540
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001443540 019__ $$a1290841690$$a1291146237$$a1291170858
001443540 020__ $$a9783030898731$$q(electronic bk.)
001443540 020__ $$a3030898733$$q(electronic bk.)
001443540 020__ $$z9783030898724$$q(print)
001443540 020__ $$z3030898725
001443540 0247_ $$a10.1007/978-3-030-89873-1$$2doi
001443540 035__ $$aSP(OCoLC)1291277750
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001443540 050_4 $$aRC159.A5
001443540 08204 $$a616.9/362061$$223
001443540 1001_ $$aKingston, David G. I.,$$eauthor.
001443540 24510 $$aAntimalarial natural products /$$cA. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Yoshinori Asakawa, Ji-Kai Liu, Verena M. Dirsch, editors ; by David G. I. Kingston and Maria Belen Cassera.
001443540 264_1 $$aCham, Switzerland :$$bSpringer,$$c2022.
001443540 300__ $$a1 online resource (ix, 106 pages) :$$billustrations (some color).
001443540 336__ $$atext$$btxt$$2rdacontent
001443540 337__ $$acomputer$$bc$$2rdamedia
001443540 338__ $$aonline resource$$bcr$$2rdacarrier
001443540 4901_ $$aProgress in the chemistry of organic natural products,$$x2192-4309 ;$$vvolume 117
001443540 506__ $$aAccess limited to authorized users.
001443540 520__ $$aThis volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine's biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine's structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature's combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends by identifying ten natural products with development potential as clinical antimalarial agents.
001443540 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed January 7, 2022).
001443540 650_0 $$aAntimalarials.
001443540 650_0 $$aNatural products.
001443540 650_6 $$aAntipaludiques.
001443540 650_6 $$aProduits naturels.
001443540 655_0 $$aElectronic books.
001443540 7001_ $$aCassera, Maria Belen,$$eauthor.
001443540 7001_ $$aKinghorn, A. Douglas,$$eeditor.$$1https://orcid.org/0000-0002-6647-8707
001443540 7001_ $$aFalk, Heinz,$$d1939-$$eeditor.$$1https://orcid.org/0000-0001-9978-4105
001443540 7001_ $$aGibbons, Simon$$c(Professor of medicinal phytochemistry),$$eeditor.$$1https://orcid.org/0000-0002-4732-7305
001443540 7001_ $$aAsakawa, Yoshinori,$$eeditor.$$1https://orcid.org/0000-0002-1847-412X
001443540 7001_ $$aLiu, Ji-Kai,$$eeditor.$$0(orcid)0000-0001-6279-7893$$1https://orcid.org/0000-0001-6279-7893
001443540 7001_ $$aDirsch, Verena M.$$eeditor.$$0(orcid)0000-0002-9261-5293$$1https://orcid.org/0000-0002-9261-5293
001443540 77608 $$iPrint version: $$z3030898725$$z9783030898724$$w(OCoLC)1269092181
001443540 830_0 $$aProgress in the chemistry of organic natural products (2011) ;$$v117.$$x2192-4309
001443540 852__ $$bebk
001443540 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-89873-1$$zOnline Access$$91397441.1
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001443540 980__ $$aBIB
001443540 980__ $$aEBOOK
001443540 982__ $$aEbook
001443540 983__ $$aOnline
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