Tumor suppressor Par-4 : structural features, molecular mechanisms and function / Vivek M. Rangnekar, editor.

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Tumor suppressor Par-4 : structural features, molecular mechanisms and function / Vivek M. Rangnekar, editor.

9783030735722 (electronic bk.)
3030735729 (electronic bk.)
9783030735715

Cham : Springer, [2022]

©2022

English

1 online resource (x, 323 pages) : illustrations (chiefly color)

10.1007/978-3-030-73572-2 doi

QR188.6 .T86 2022

612/.01575

Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar's laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule's structural features, key functional domains, regulation and relevant basic and clinical/translational facets.

Includes index.

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Online resource; title from PDF title page (SpringerLink, viewed January 12, 2022).

Print version: 9783030735715
Print version: 9783030735739

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