001443761 000__ 04723cam\a2200553Ii\4500 001443761 001__ 1443761 001443761 003__ OCoLC 001443761 005__ 20230310003600.0 001443761 006__ m\\\\\o\\d\\\\\\\\ 001443761 007__ cr\cn\nnnunnun 001443761 008__ 220120s2022\\\\sz\a\\\\o\\\\\001\0\eng\d 001443761 019__ $$a1290814278$$a1290840633$$a1291318931$$a1292358136 001443761 020__ $$a9783030871048$$q(electronic bk.) 001443761 020__ $$a3030871045$$q(electronic bk.) 001443761 020__ $$z9783030871031 001443761 020__ $$z3030871037 001443761 0247_ $$a10.1007/978-3-030-87104-8$$2doi 001443761 035__ $$aSP(OCoLC)1292734247 001443761 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dYDX$$dEBLCP$$dOCLCO$$dOCLCF$$dOCLCO$$dN$T$$dOCLCQ 001443761 049__ $$aISEA 001443761 050_4 $$aRC732 001443761 08204 $$a616.20041$$223 001443761 24504 $$aThe microbiome in respiratory disease :$$bprinciples, tools and applications /$$cedited by Yvonne Huang, Stavros Garantziotis. 001443761 264_1 $$aCham, Switzerland :$$bHumana Press,$$c2022. 001443761 300__ $$a1 online resource (1 volume) :$$billustrations (color). 001443761 336__ $$atext$$btxt$$2rdacontent 001443761 337__ $$acomputer$$bc$$2rdamedia 001443761 338__ $$aonline resource$$bcr$$2rdacarrier 001443761 4901_ $$aRespiratory medicine 001443761 500__ $$aIncludes index. 001443761 5050_ $$aSECTION I: Principles and Tools of Respiratory Microbiome Investigation -- Conceptual Framework and Hypothesis Testing -- Study Design and Sampling Considerations -- Laboratory Platforms to Study the Microbiome -- Analysis and Reporting of Microbiome Data -- SECTION II: Applications in the Study of Specific Diseases -- Chronic Rhinosinusitis /Allergic Rhinitis -- Bronchiolitis, Viral Infection and Pediatric Asthma Risk -- Asthma Pheotype -- Cystic Fibrosis -- Bronchiectasis (non-CF) -- COPD -- Idiopathic Pulmonary Fibrosis -- Lung Transplantation and Immune Suppression -- The Future: Knowledge gaps and priorities. 001443761 506__ $$aAccess limited to authorized users. 001443761 520__ $$aThis book comprehensively covers the microbiome in respiratory disease, from the initial research study to the disease-specific implications and related applications. Research on the respiratory microbiome is increasing in volume and scope. This reflects rapidly growing interest in the study of respiratory disease to understand how microbiota shape mechanisms of disease pathogenesis. The respiratory tract spans the nasal passages, sinus cavities, oropharynx, and the tracheobronchial tree of the lungs. In these compartments of the upper and lower respiratory tract, the microbiota have now been studied in the context of several chronic respiratory conditions. These include chronic sinusitis, allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis and pulmonary fibrosis, to name a few. The potential impact of ecological interactions (i.e., between microbes and between microbiota and host) within and across respiratory compartments is increasingly recognized. The book is organized into two main sections. Part I, Principles and Tools, covers conceptual modeling of the respiratory microbiome, experimental methodology with a focus on a priori considerations in study design and sampling, laboratory and computational methods for analysis of respiratory microbiome data, and minimizing interpretive pitfalls. Part II, Applications, discusses the evidence from specific studies that have shed novel insights into the influence of respiratory microbiota on mechanisms or outcomes in specific diseases. Based on current best evidence, disease-specific chapters include chronic rhinosinusitis, asthma (pediatric and adult studies), chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), bronchiectasis not due to CF, idiopathic pulmonary fibrosis, and lung transplant. This is an ideal reference for forward-thinking practitioners with interest in novel developments in precision medicine applications in lung disease, as well as translational scientists in the field of microbiology, immunology and lung biology. 001443761 588__ $$aDescription based on print version record. 001443761 650_0 $$aRespiratory organs$$xDiseases$$xMicrobiology. 001443761 650_0 $$aMedical microbiology. 001443761 650_6 $$aAppareil respiratoire$$xMaladies$$xMicrobiologie. 001443761 650_6 $$aMicrobiologie médicale. 001443761 655_0 $$aElectronic books. 001443761 7001_ $$aHuang, Yvonne,$$eeditor. 001443761 7001_ $$aGarantziotis, Stavros,$$eeditor. 001443761 77608 $$iPrint version:$$tMicrobiome in respiratory disease.$$dCham : Springer, 2022$$z9783030871031$$w(OCoLC)1289271371 001443761 830_0 $$aRespiratory medicine (New York, N.Y.) 001443761 852__ $$bebk 001443761 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-87104-8$$zOnline Access$$91397441.1 001443761 909CO $$ooai:library.usi.edu:1443761$$pGLOBAL_SET 001443761 980__ $$aBIB 001443761 980__ $$aEBOOK 001443761 982__ $$aEbook 001443761 983__ $$aOnline 001443761 994__ $$a92$$bISE