Principles of genetics and molecular epidemiology / Juan Carlos Gomez-Verjan, Nadia Alejandra Rivero-Segura, editors.
Gomez-Verjan, Juan Carlos, editor.; Rivero-Segura, Nadia Alejandra, editor.
2022
RA652.5
Available Online

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Title Principles of genetics and molecular epidemiology / Juan Carlos Gomez-Verjan, Nadia Alejandra Rivero-Segura, editors.
ISBN 9783030896010 (electronic bk.)
3030896013 (electronic bk.)
3030896005
9783030896003
DOI https://doi.org/10.1007/978-3-030-89601-0
Publication Details Cham, Switzerland : Springer, 2022.
Language English
Description 1 online resource
Item Number 10.1007/978-3-030-89601-0 doi
Call Number RA652.5
Dewey Decimal Classification 614.4
Summary This book covers some of the most novel genetic and genomic concepts in epidemiology, such as geospatial statistics and systems biology from a clinical point of view by explaining molecular applications with accessible human studies. Featuring a comprehensive table of contents, it includes chapters from genomics and epidemiology surveillance to transcriptomics and alternative splicing principles. Across 17 well-organized chapters, this book meets attempt to explain easily to clinicians and students with basic principles of the genetics, genomics, molecular biology and its applications to epidemiology and public health. The text is distinct from other literature on the market because it covers useful genomic tools applied in epidemiology for clinicians who may not be experts in this branch of health science. Principles of Genetics and Molecular Epidemiology demystifies the idea that biomedicine is far from being applied in both epidemiology and clinical practice.
Note Includes index.
Bibliography, etc. Note References -- 2: Molecular Tools for Modern Epidemiology: From the Concepts to Clinical Applications -- Introduction -- PCR -- Types of PCR -- Multiplex PCR -- Real-Time PCR -- Reverse Transcription PCR -- Digital PCR -- Lamp -- Principles of Karyotyping -- FISH -- Microarray -- Immunoassays -- Enzyme-Linked Immunosorbent Assay (ELISA) -- Direct ELISA (Antigen-Coated Plate, Screening Antibody) -- Indirect ELISA (Antigen-Coated Plate -- Screening Antigen/Antibody) -- Sandwich ELISA (Antibody-Coated Plate -- Screening Antigen) -- Competitive ELISA (Screening Antibody) -- New Methods.
Access Note Access limited to authorized users.
Digital File Characteristics text file PDF
Source of Description Online resource; title from PDF title page (SpringerLink, viewed February 8, 2022).
Added Author Gomez-Verjan, Juan Carlos, editor.
Rivero-Segura, Nadia Alejandra, editor.
Available in Other Form Print version: 9783030896003
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Intro
Foreword
References
Preface
Acknowledgements
Contents
Contributors
1: Principles of Modern Epidemiology and Public Health
Introduction
Life-Course Epidemiology
Principles of Life-Course Research
Development over Time
Time and Place
Timing
Linked Lives
Free Will or Agency
Challenges for Life-Course Epidemiology
Translational Epidemiology
Postmodern Epidemiology
Need for a Refocus on Postmodern Epidemiology
Analysis Levels to be Considered in Postmodern Epidemiology
Postmodern Epidemiology Perspective
Final Considerations

Clinical Significance
Western Blot
Multiplex Western Blot (MWB)
Capillary Electrophoresis (CE) and Capillary Western Blotting (CWB)
Microfluidic Western Blotting
Single-Cell Western Blotting
Dot Blot
Far-Western Blotting
Clinical Significance
Flow Cytometry
Clinical Applications
Phenotypic Characterization of Blood Cells
Intracellular Antigen Expression
Characterization of Antigen-Specific Responses
Cell Cycle Analysis
Apoptosis
Proteomics
Studying the Proteome
Concluding Remarks
References
3: Genomic Tools in Clinical Epidemiology

Introduction
NGS in the Study of Relevant SNVs and SNPs for Epidemiological Surveillance
Implication of NGS Technologies on the Control of SARS-CoV-2 Pandemic
The Influence of Genomic Tools on the Management of Helicobacter pylori Infection
General Applications of NGS Technologies in Oncology Practices
Advances on the Pathogenesis and Treatment Knowledge of Rheumatoid Arthritis by Using NGS
Concluding Remarks
References
4: Epigenetics in Epidemiology
Introduction
Epigenetic Process
Epigenetic Technology Analysis
Overview of Bioinformatic Analysis of Epigenome

Epigenetic Biomarkers
Epigenetics in Pharmacology
Conclusions
References
5: Principles of Clinical Transcriptomics and Splicing
Introduction
The Leap From Classic Gene Expression Studies to Transcriptomics
General Overview of Transcriptomic Technologies
SAGE-Derived Sequencing Technologies
Microarrays
RNA-seq
Bulk Transcriptomics Profiling and Single-Cell Transcriptomics
Splicing and Alternative Splicing
Implications of Alternative Splicing in Clinics
Applications of Transcriptomics in Clinical Disease
Concluding Remarks
References

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