001445428 000__ 04297cam\a2200613Ii\4500 001445428 001__ 1445428 001445428 003__ OCoLC 001445428 005__ 20230310003830.0 001445428 006__ m\\\\\o\\d\\\\\\\\ 001445428 007__ cr\un\nnnunnun 001445428 008__ 220327s2022\\\\sz\a\\\\ob\\\\000\0\eng\d 001445428 019__ $$a1306052306 001445428 020__ $$a9783030910518$$q(electronic bk.) 001445428 020__ $$a3030910512$$q(electronic bk.) 001445428 020__ $$z9783030910501 001445428 020__ $$z3030910504 001445428 0247_ $$a10.1007/978-3-030-91051-8$$2doi 001445428 035__ $$aSP(OCoLC)1306022517 001445428 040__ $$aYDX$$beng$$erda$$epn$$cYDX$$dGW5XE$$dOCLCO$$dEBLCP$$dOCLCF$$dUKAHL$$dOCLCQ 001445428 049__ $$aISEA 001445428 050_4 $$aRA776.5$$b.E86 2022 001445428 08204 $$a613$$223 001445428 24500 $$aEvolution, biodiversity and a reassessment of the hygiene hypothesis /$$cGraham A.W. Rook, Christopher A. Lowry, editors. 001445428 264_1 $$aCham :$$bSpringer,$$c[2022] 001445428 264_4 $$c©2022 001445428 300__ $$a1 online resource :$$billustrations (chiefly color). 001445428 336__ $$atext$$btxt$$2rdacontent 001445428 337__ $$acomputer$$bc$$2rdamedia 001445428 338__ $$aonline resource$$bcr$$2rdacarrier 001445428 4901_ $$aProgress in inflammation research ;$$vvolume 89 001445428 504__ $$aIncludes bibliographical references. 001445428 5050_ $$aChapter 1. From observing children in traditional upbringing to concepts of health -- Chapter 2. Human evolution, microorganisms, socioeconomic status and reconciling necessary microbial exposures with essential hygiene -- Chapter 3. Biodiversity, microbiomes, and human health -- Chapter 4. Regulation of host immunity by the gut microbiota -- Chapter 5. The gut microbiota and host metabolism -- Chapter 6. The impacts of the microbiota on animal development and physiology -- Chapter 7. The development of the gut microbiota in childhood, and its distortion by lifestyle changes -- Chapter 8. Distortion of the microbiota of the natural environment by human activities -- Chapter 9. The nature and functions of vertebrate skin microbiota -- Chapter 10. The influence of the microbiota on brain structure and function: Implications for stress-related neuropsychiatric disorders -- Chapter 11. Neurodegenerative diseases and the gut microbiota -- Chapter 12. Clinical application of the biodiversity hypothesis in the management of allergic disorders. . 001445428 506__ $$aAccess limited to authorized users. 001445428 520__ $$aThis edited collection of 12 chapters by research workers from a wide range of disciplines resolves the confusion that currently surrounds the "hygiene hypothesis" by considering the human need for exposure to microorganisms from an evolutionary point of view. The book explains why we evolved a requirement for exposure to microbiota from our mothers, from other people, and from the natural environment. It also explains the physiological roles of these exposures, what goes wrong when the exposures are distorted and how human lifestyles and activities, including degradation of the natural environment, are leading to this distortion. Particular attention is given to the range of pathologies associated with inappropriate microbial exposures and inappropriate colonization, including immunoregulatory problems such as allergies and autoimmunity, metabolic problems such as obesity and diabetes, and problems of central nervous system function and neurodegeneration. This book is of profound relevance to most medical disciplines, but also to those concerned with preserving the natural environment and with developing healthier urbanisation. 001445428 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed March 30, 2022). 001445428 650_0 $$aHealth. 001445428 650_0 $$aHygiene. 001445428 650_0 $$aMedical microbiology. 001445428 650_0 $$aHuman evolution. 001445428 650_6 $$aSanté. 001445428 650_6 $$aHygiène. 001445428 650_6 $$aMicrobiologie médicale. 001445428 650_6 $$aHomme$$xÉvolution. 001445428 655_0 $$aElectronic books. 001445428 7001_ $$aRook, G. A. W.$$q(Graham A. W.),$$d1946-$$eeditor. 001445428 7001_ $$aLowry, Christopher A.,$$eeditor. 001445428 77608 $$iPrint version: $$z3030910504$$z9783030910501$$w(OCoLC)1277281059 001445428 830_0 $$aPIR (Series) ;$$vv. 89. 001445428 852__ $$bebk 001445428 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-91051-8$$zOnline Access$$91397441.1 001445428 909CO $$ooai:library.usi.edu:1445428$$pGLOBAL_SET 001445428 980__ $$aBIB 001445428 980__ $$aEBOOK 001445428 982__ $$aEbook 001445428 983__ $$aOnline 001445428 994__ $$a92$$bISE