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1. Introduction
2. Pathogenesis of refractory celiac disease (I): role of virus and microbiota
3.Pathogenesis of refractory celiac disease (II): from refractory celiac disease to overt lymphoma
4. Pathogenesis of refractory celiac disease (III): genetic basis.-5. From unresponsive celiac disease to refractory celiac disease
6. Epidemiology of refractory celiac disease
7. Diagnosis of refractory celiac disease: Isolation-flow phenotyping and clonality
8.Diagnosis of refractory celiac disease: pathology
9. The other causes of severe enteropathy with villous atrophy non responsive to a gluten free diet
10.Treatment of Refractory Celiac disease.

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