Aging mechanisms II : longevity, metabolism, and brain aging / Nozomu Mori, editor.
Mori, Nozomu, editor.
2022
QP86
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Title Aging mechanisms II : longevity, metabolism, and brain aging / Nozomu Mori, editor.
ISBN 9789811679773 (electronic bk.)
9811679770 (electronic bk.)
9811679762
9789811679766
DOI https://doi.org/10.1007/978-981-16-7977-3
Published Singapore : Springer, [2022]
Copyright ©2022
Language English
Description 1 online resource : illustrations (some color)
Item Number 10.1007/978-981-16-7977-3 doi
Call Number QP86
Dewey Decimal Classification 612.6/7
Summary This book describes the recent advancement of basic research on the biology of aging and longevity studies in various organisms, as well as the neurobiology of aging and neurodegeneration mechanisms. Chapters present new findings and conceptual developments concerning the basic mechanisms of aging and longevity determination. As a follow-up volume to the previous book Aging Mechanisms (2015), it overviews the rapid progress of aging research introducing new topics from leading laboratories in Japan. Chapter contributors are selected based on recent scientific achievements on the mechanisms of aging in various model organisms, including yeast, worm (C. elegans), fly (Drosophila), mice, and rats. Chapters are ordered from the discussion on molecular and cellular levels to physiological and systemic levels. The book also provides an overview of aging science in the region and helps readers quickly grasp who is doing what in this research area. As the aging of population becomes an ever more pressing issue in Asia, advancing the understanding of basic mechanisms of organism aging and longevity determination will be crucial to developing more effective therapies and protective strategies. Researchers and graduate students in biomedical aging research will find this as a rich source of information and a stimulus to novel research directions.
Note Includes index.
Access Note Access limited to authorized users.
Source of Description Description based on print version record.
Added Author Mori, Nozomu, editor.
Available in Other Form AGING MECHANISMS II.
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Chapter 1. An Unsolved Problem in Gerontology Yet : The Molecular Mechanism of Biological Aging A Historical and Critical Overview
Chapter 2. Clinical and Basic Biology of Werner Syndrome, the Model Disease of Human Aging
Chapter 3. Biomarkers of Healthy Longevity: Lessons from Supercentenarians in Japan
Chapter 4. Cellular aging and metabolites in aging
Chapter 5. To G0 or Not to G0: Cell Cycle Paradox in Senescence and Brain Aging
Chapter 6. C. elegans longevity genes
Chapter 7. Understanding the functions of longevity genes in Drosophila
Chapter 8. NAD+ metabolism in Aging
Chapter 9. Mitochondrial dysfunction and growth differentiation factor 15 in aging
Chapter 10. Sirtuins and metabolic health
Chapter 11. Autophagy in aging and longevity
Chapter 12. Sarcopenia: current topics and future perspective
Chapter 13. Osteoporosis and cellular senescence in bone
Chapter 14. Aging and chronic kidney disease viewed from the FGF-Klotho endocrine system
Chapter 15. Aging biomarker SMP30 into a new phase of vitamin C and aging research
Chapter 16. Age-related memory impairments are caused by alterations in glial activity at old ages
Chapter 17. Critical Roles of Glial Neuroinflammation in Age-Related Memory Decline
Chapter 18. Central mechanisms linking age-associated physiological changes to healthspan through the hypothalamus
Chapter 19. PET imaging of amyloid and tau in Alzheimers disease
Chapter 20. Presenilin/[gamma]-secretase in the pathogenesis of Alzheimer disease
Chapter 21. Amyloid-[beta] in brain aging and Alzheimers disease
Chapter 22. Tau Pathology and Neurodegenerative Disorders
Chapter 23. Aging and Parkinsons disease: pathological insight on model mice
Chapter 24. Evaluating the brain aging through eyes: The Potential use of hyperspectral imaging cameras to diagnose Alzheimer's disease risk
Chapter 25. Healthy Aging in Japan.

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