Concurrent users
Unlimited
Authorized users
Authorized users
Document Delivery Supplied
Can lend chapters, not whole ebooks
Title
Formulating poorly water soluble drugs.
Edition
Third edition / Robert O. Williams III, Daniel A. Davis, Jr., Dave A. Miller, editors.
ISBN
9783030887193 (electronic bk.)
3030887197 (electronic bk.)
9783030887186
3030887189
Published
Cham : Springer, [2022]
Copyright
©2022
Language
English
Description
1 online resource : illustrations (some color).
Item Number
10.1007/978-3-030-88719-3 doi
Call Number
RM301.25
Dewey Decimal Classification
615.1/9
Summary
The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientists approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compounds physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop. Highlights the most recent advancements reported in the literature on technologies to improve the dissolution and bioavailability of poorly water soluble drugs Provides a comprehensive discussion of new technologies developed and recently over 40% updated new content Essential read for scientists and researchers in pharmaceutical, chemical, and agricultural industries since over 80% of newly discovered drugs are poorly water soluble.
Note
Includes index.
Access Note
Access limited to authorized users.
Source of Description
Description based on print version record.
Series
AAPS advances in the pharmaceutical sciences series ; v. 50.
Route-Specific Challenges in the Delivery of Poorly Water-Soluble Drugs
Optimizing the Formulation of Poorly Water-Soluble Drugs
Solid-State Techniques for Improving Solubility
Mechanical Particle-Size Reduction Techniques
Co-solvent and Complexation Systems
Injectable Formulations of Poorly Water-Soluble Drugs
Lipid-Based Formulations
Structured Development Approach for Amorphous Systems
Melt Extrusion
Spray-Drying Technology
Pharmaceutical Cryogenic Technologies
Precipitation Technologies for Nanoparticle Production
Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs
Scientific and Regulatory Considerations for Development and Commercialization of Poorly Water-Soluble Drugs.
