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Table of Contents
Part I-Physiology and Basic Principles of Drug Handling for the CNS
Anatomy and Physiology of the Blood Brain Barriers
Drug Delivery to the Brain: Integrating Neuroscience, Physiology, and Brain Barriers Science
Brain Delivery of Therapeutics via Transcytosis: Types and Mechanisms of Vesicle-Mediated Transport Across the BBB
Brain- Arachnoid Barrier as an Important Clearance Pathway from CSF
BBB Pharmacoproteomics: Quantitative Targeted Absolute Proteomics (QTAP): Species Differences
Drug Metabolism at the BBB and the BCFSB
PART II-PK Concepts and Methods for Studying CNS Drug Delivery
Pharmacokinetics Concepts in Brain Drug Delivery
In Vitro Models of CNS Barriers
Human In Vitro BBB Models Derived from Pluripotent Stem Cells
In situ and In vivo Animal Models
Principles of PET and Its Role in Understanding Drug Delivery to the Brain
Prediction of CNS PK and PD Using Translational Research Approaches
Part III-Industrial Approaches for Investigation of Potential CNS Drugs
Drug Discovery Methods for Studying Brain Drug Delivery and Distribution
Prediction of Drug Exposure in the Brain From the Chemical Structure
Integrated Approach to Optimizing CNS Penetration in Drug Discovery
Part IV: Strategies for Improved CNS Drug Delivery
Intranasal Drug Delivery to the Brain
Blood to Brain Drug Delivery Using Nanocarriers
Enhancing CNS Exposure Through Brain Endothelial Cell RMT-Exploiting the Transferrin Receptor at the BBB
Therapeutic Osmotic Modification of the BBB in the Treatment of CNS Pathologies
Biophysical Perspectives on BBB Permeability Enhancement by Ultrasound and Microbubbles for Targeted Drug Delivery in the Clinical Setting
Optimization of Blood Brain Barrier Opening With Focused Ultrasound-The Animal Perspective
CNS Gene Therapy Using Adeno-Associated Virus (AAV) Vectors
Part V-CNS Drug Delivery in Disease Conditions
Disease Influence on BBB Transport in Neurodegeneration and Neuroinflammation
Enhancing Drug Delivery in the Setting of Stroke and Brain Injury
Drug Delivery to tumor Metastases in the Brain-(Including PK PD Free Fraction Active Conc.)
Drug Delivery to Primary Tumors in the Brain-(Including PK PD Free Fraction Active Conc.)
Appendix:CNS Anatomy, Function, Vasculature and Fluid Exchange: Primer for Drug Delivery Scientists.
Anatomy and Physiology of the Blood Brain Barriers
Drug Delivery to the Brain: Integrating Neuroscience, Physiology, and Brain Barriers Science
Brain Delivery of Therapeutics via Transcytosis: Types and Mechanisms of Vesicle-Mediated Transport Across the BBB
Brain- Arachnoid Barrier as an Important Clearance Pathway from CSF
BBB Pharmacoproteomics: Quantitative Targeted Absolute Proteomics (QTAP): Species Differences
Drug Metabolism at the BBB and the BCFSB
PART II-PK Concepts and Methods for Studying CNS Drug Delivery
Pharmacokinetics Concepts in Brain Drug Delivery
In Vitro Models of CNS Barriers
Human In Vitro BBB Models Derived from Pluripotent Stem Cells
In situ and In vivo Animal Models
Principles of PET and Its Role in Understanding Drug Delivery to the Brain
Prediction of CNS PK and PD Using Translational Research Approaches
Part III-Industrial Approaches for Investigation of Potential CNS Drugs
Drug Discovery Methods for Studying Brain Drug Delivery and Distribution
Prediction of Drug Exposure in the Brain From the Chemical Structure
Integrated Approach to Optimizing CNS Penetration in Drug Discovery
Part IV: Strategies for Improved CNS Drug Delivery
Intranasal Drug Delivery to the Brain
Blood to Brain Drug Delivery Using Nanocarriers
Enhancing CNS Exposure Through Brain Endothelial Cell RMT-Exploiting the Transferrin Receptor at the BBB
Therapeutic Osmotic Modification of the BBB in the Treatment of CNS Pathologies
Biophysical Perspectives on BBB Permeability Enhancement by Ultrasound and Microbubbles for Targeted Drug Delivery in the Clinical Setting
Optimization of Blood Brain Barrier Opening With Focused Ultrasound-The Animal Perspective
CNS Gene Therapy Using Adeno-Associated Virus (AAV) Vectors
Part V-CNS Drug Delivery in Disease Conditions
Disease Influence on BBB Transport in Neurodegeneration and Neuroinflammation
Enhancing Drug Delivery in the Setting of Stroke and Brain Injury
Drug Delivery to tumor Metastases in the Brain-(Including PK PD Free Fraction Active Conc.)
Drug Delivery to Primary Tumors in the Brain-(Including PK PD Free Fraction Active Conc.)
Appendix:CNS Anatomy, Function, Vasculature and Fluid Exchange: Primer for Drug Delivery Scientists.