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4.3.2 DFT and QM/MM Studies of Alkyl Sulfide
4.3.2.1 Sulfoxidation by Cpd 0 and Cpd I
4.3.2.2 Radical Clock Experiment
Rebound Controversy and Its Resolution by TSR Scenarios
4.3.2.3 Products Isotope Effect and TSR
4.3.2.4 Quantum Mechanical and Molecular Mechanical Application in Biomedical
4.4 Establishing and Testing Reaction Mechanisms
4.4.1 Lysozymes
4.4.2 Citrate Synthase
4.5 QM/MM Modeling of Drug Target Enzyme
4.5.1 Fatty-Acid Amide Hydrolase (FAAH)
4.5.2 Zn Enzymatic Drug Metabolism: Antibiotic Hydrolysis by Metallo-[beta]-Lactamases Enzymes
4.6 Summary
Intro
Preface
Contents
About the Editors
1: Introduction to Emerging Technologies in Biomedical Sciences
1.1 Introduction
1.2 Imaging Cells to Molecules in 3D
1.3 Genetic Engineering with Precision
1.4 Omics Technologies
1.5 Next-Generation Sequencing
1.6 Spectroscopy of Single-Molecule and Mixtures
1.7 Informatics and Simulations
1.8 Automation and Miniaturization of Experiments (Robotic Liquid Handling Systems and Microfluidics)
1.9 Microelectromechanical Systems in Biology (Bio-MEMS)
1.10 Personalized Medicine
1.11 Exosomes in Cancer Immunotherapy
1.12 Neuronal Tracing Techniques
1.13 Miniaturized Bioreactors
1.14 Transcranial Magnetic Stimulation (TMS)
1.15 Bionic Organism or Cyborg Cells
1.16 Conclusion
References
2: Bioprospecting: Boon or Curse
2.1 United Nations Convention on Biological Diversity.
2.2 Virtues of Bioprospecting
2.3 Demons of Bioprospecting
2.4 Resolution to the Concerns
2.5 Conclusions and Future Prospects
References
3: Growing Need for Interdisciplinary Biomedical Research
3.1 Introduction
3.2 Interdisciplinary Research
3.2.1 Cardiovascular Health and Diseases
3.2.2 Studies on Pathogens
3.2.3 Schizophrenia
3.3 Increasing Urgency in Some Fields of Research
3.4 Why Do We Need Interdisciplinary Research?
3.5 Future Directions for Interdisciplinary Research
3.6 Concluding Remarks
References
4: Interplay Between Theory and Experiment: A Future Approach for Biomedical Research
4.1 History
4.2 Introduction
4.2.1 Cytochrome P450 (P450)
4.3 Experiment That Created Doubt
4.3.1 Site-Directed Mutagenesis
4.3.1.1 Ethylene Epoxidation by CPD 0 and CPD I
4.3.2.1 Sulfoxidation by Cpd 0 and Cpd I
4.3.2.2 Radical Clock Experiment
Rebound Controversy and Its Resolution by TSR Scenarios
4.3.2.3 Products Isotope Effect and TSR
4.3.2.4 Quantum Mechanical and Molecular Mechanical Application in Biomedical
4.4 Establishing and Testing Reaction Mechanisms
4.4.1 Lysozymes
4.4.2 Citrate Synthase
4.5 QM/MM Modeling of Drug Target Enzyme
4.5.1 Fatty-Acid Amide Hydrolase (FAAH)
4.5.2 Zn Enzymatic Drug Metabolism: Antibiotic Hydrolysis by Metallo-[beta]-Lactamases Enzymes
4.6 Summary
Intro
Preface
Contents
About the Editors
1: Introduction to Emerging Technologies in Biomedical Sciences
1.1 Introduction
1.2 Imaging Cells to Molecules in 3D
1.3 Genetic Engineering with Precision
1.4 Omics Technologies
1.5 Next-Generation Sequencing
1.6 Spectroscopy of Single-Molecule and Mixtures
1.7 Informatics and Simulations
1.8 Automation and Miniaturization of Experiments (Robotic Liquid Handling Systems and Microfluidics)
1.9 Microelectromechanical Systems in Biology (Bio-MEMS)
1.10 Personalized Medicine
1.11 Exosomes in Cancer Immunotherapy
1.12 Neuronal Tracing Techniques
1.13 Miniaturized Bioreactors
1.14 Transcranial Magnetic Stimulation (TMS)
1.15 Bionic Organism or Cyborg Cells
1.16 Conclusion
References
2: Bioprospecting: Boon or Curse
2.1 United Nations Convention on Biological Diversity.
2.2 Virtues of Bioprospecting
2.3 Demons of Bioprospecting
2.4 Resolution to the Concerns
2.5 Conclusions and Future Prospects
References
3: Growing Need for Interdisciplinary Biomedical Research
3.1 Introduction
3.2 Interdisciplinary Research
3.2.1 Cardiovascular Health and Diseases
3.2.2 Studies on Pathogens
3.2.3 Schizophrenia
3.3 Increasing Urgency in Some Fields of Research
3.4 Why Do We Need Interdisciplinary Research?
3.5 Future Directions for Interdisciplinary Research
3.6 Concluding Remarks
References
4: Interplay Between Theory and Experiment: A Future Approach for Biomedical Research
4.1 History
4.2 Introduction
4.2.1 Cytochrome P450 (P450)
4.3 Experiment That Created Doubt
4.3.1 Site-Directed Mutagenesis
4.3.1.1 Ethylene Epoxidation by CPD 0 and CPD I