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001447417 001__ 1447417
001447417 003__ OCoLC
001447417 005__ 20230310004117.0
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001447417 019__ $$a1329425193
001447417 020__ $$a9783031065125$$q(electronic bk.)
001447417 020__ $$a3031065123$$q(electronic bk.)
001447417 020__ $$z3031065115
001447417 020__ $$z9783031065118
001447417 0247_ $$a10.1007/978-3-031-06512-5$$2doi
001447417 035__ $$aSP(OCoLC)1328137202
001447417 040__ $$aEBLCP$$beng$$epn$$cEBLCP$$dGW5XE$$dYDX$$dEBLCP$$dOCLCF$$dOCLCQ$$dEMU$$dOCLCQ
001447417 049__ $$aISEA
001447417 050_4 $$aQH603.C43
001447417 08204 $$a616.079$$223/eng/20220616
001447417 24500 $$aToll-Like receptors in health and disease /$$cVijay Kumar, editor.
001447417 260__ $$aCham :$$bSpringer,$$c2022.
001447417 300__ $$a1 online resource (316 pages)
001447417 336__ $$atext$$btxt$$2rdacontent
001447417 337__ $$acomputer$$bc$$2rdamedia
001447417 338__ $$aonline resource$$bcr$$2rdacarrier
001447417 4901_ $$aHandbook of experimental pharmacology ;$$vv. 276
001447417 5050_ $$aIntracellular TLRs (TLR3, TLR7, and TRL9) in host defense or TLRs in mast cells -- Toll-like receptors as drug targets in the intestinal epithelium -- Innate immune memory-priming, tolerance and exhaustion-in health and disease -- TLRs in brain immunity -- TLRs in cerebrovascular diseases -- TLRs in stem cells or progenitor cells -- TLRs in adaptive immunity -- Overview on TLRs in immunity -- TLR10 and its role in immunity.
001447417 506__ $$aAccess limited to authorized users.
001447417 520__ $$aThe current book is focussed on the Toll-like receptors (TLRs), which are the first pattern recognition receptors (PRRs) discovered in humans. For example, TLR4 was first recognized in humans in 1997 as a PRR recognizing the Gram-negative bacterial lipopolysaccharide (LPS). This discovery revolutionized the field of innate immunity and filled the long-standing gap in the pathogen recognition by the immune system. Now, it is well established that humans have 10 (TLR1-TLR10) and mice have 12 (TLR1-TLR13) functional TLRs, excluding TLR10 that is present as a defective pseudogene. TLRs are present as both membrane-bound extracellular (TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10) and intracellular (TLR3, TLR7, TLR8, and TLR9) PRRs in humans, which identify different pathogen or microbe-associated molecular patterns (PAMPs or MAMPs) and death or damage-associated molecular patterns (DAMPs) released by the host cells. A lot of development in the TLR biology has occurred in last 24 years since there first discovery in humans. The book is intended to describe their role in the host defence, human reproduction, non-infectious sterile inflammatory conditions, including brain immunity and cerebrovascular diseases, signaling mechanisms, adaptive immunity, and their targeting for drug development.
001447417 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed June 16, 2022).
001447417 650_0 $$aCell receptors.
001447417 655_0 $$aElectronic books.
001447417 7001_ $$aKumar, Vijay$$c(Expert in medical bacteriology and immunology)
001447417 77608 $$iPrint version:$$aKumar, Vijay.$$tToll-Like Receptors in Health and Disease.$$dCham : Springer International Publishing AG, ©2022$$z9783031065118
001447417 830_0 $$aHandbook of experimental pharmacology ;$$vv. 276.
001447417 852__ $$bebk
001447417 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-06512-5$$zOnline Access$$91397441.1
001447417 909CO $$ooai:library.usi.edu:1447417$$pGLOBAL_SET
001447417 980__ $$aBIB
001447417 980__ $$aEBOOK
001447417 982__ $$aEbook
001447417 983__ $$aOnline
001447417 994__ $$a92$$bISE