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001447844 001__ 1447844
001447844 003__ OCoLC
001447844 005__ 20230310004138.0
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001447844 019__ $$a1334106282
001447844 020__ $$a9789811929168$$q(electronic bk.)
001447844 020__ $$a9811929165$$q(electronic bk.)
001447844 020__ $$z9811929157
001447844 020__ $$z9789811929151
001447844 0247_ $$a10.1007/978-981-19-2916-8$$2doi
001447844 035__ $$aSP(OCoLC)1333920781
001447844 040__ $$aYDX$$beng$$cYDX$$dGW5XE$$dEBLCP$$dOCLCF$$dN$T$$dUKAHL$$dOCLCQ
001447844 049__ $$aISEA
001447844 050_4 $$aQH491
001447844 08204 $$a571.8/33$$223/eng/20220714
001447844 1001_ $$aHonda, Hisao,$$d1943-
001447844 24510 $$aMathematical models of cell-based morphogenesis:$$bpassive and active remodeling /$$cHisao Honda,Tatsuzo Nagai.
001447844 260__ $$aSingapore :$$bSpringer,$$c2022.
001447844 300__ $$a1 online resource
001447844 4901_ $$aTheoretical biology
001447844 504__ $$aIncludes bibliographical references.
001447844 5050_ $$aChapter 1. Introduction -- Chapter 2.Cell center model -- Chapter 3.Applications of the cell center model -- Chapter 4. Vertex mode -- Chapter 5.Applications of the cell models to 2D cell patterns -- Chapter 6.3D vertex model -- Chapter 7.The world of epithelial sheets[71] -- Chapter 8.Cells themselves produce force for active remodeling -- Chapter 9.Expansion of shape-dimension -- Chapter 10.Mathematical cell models and morphogenesis.
001447844 506__ $$aAccess limited to authorized users.
001447844 520__ $$aThis book describes the shape formation of living organisms using mathematical models. Genes are deeply related to the shape of living organisms, and elucidation of a pathway of shape formation from genes is one of the fundamental problems in biology. Mathematical cell models are indispensable tools to elucidate this problem. The book introduces two mathematical cell models, the cell center model and the vertex model, with their applications. The cell center model is applied to elucidate the formation of neat cell arrangements in epidermis, cell patterns consisting of heterogeneous-sized cells, capillary networks, and the branching patterns of blood vessels. The vertex model is applied to elucidate the wound healing mechanisms of the epithelium and ordered pattern formation involving apoptosis. Pattern formation with differential cell adhesion is also described. The vertex model is then extended from a two-dimensional (2D) to a three-dimensional (3D) model. A cell aggregate involving a large cavity is described to explain the development of the mammalian blastocyst or the formation of an epithelial vesicle. Epithelial tissues and the polarity formation process of the epithelium are also explained. The vertex model also recapitulates active remodeling of tissues and describes the twisting of tissue that contributes to understanding the cardiac loop formation of the embryonic tube. The book showcases that mathematical cell models are indispensable tools to understand the shape formation of living organisms. Successful contribution of the mathematical cell models means that the remodeling of collective cells is self-construction. Examining the successive iterations of self-constructions leads to understanding the remarkable and mysterious morphogenesis that occurs during the development of living organisms. The intended readers of this book are not only theoretical or mathematical biologists, but also experimental and general biologists, including undergraduate and postgraduate students who are interested in the relationship between genes and morphogenesis. .
001447844 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed July 14, 2022).
001447844 650_0 $$aMorphogenesis$$xMathematical models.
001447844 655_0 $$aElectronic books.
001447844 7001_ $$aNagai, Tatsuzo.
001447844 77608 $$iPrint version:$$z9811929157$$z9789811929151$$w(OCoLC)1310397217
001447844 830_0 $$aTheoretical biology (Singapore)
001447844 852__ $$bebk
001447844 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-981-19-2916-8$$zOnline Access$$91397441.1
001447844 909CO $$ooai:library.usi.edu:1447844$$pGLOBAL_SET
001447844 980__ $$aBIB
001447844 980__ $$aEBOOK
001447844 982__ $$aEbook
001447844 983__ $$aOnline
001447844 994__ $$a92$$bISE