Microfluidics and multi organs on chip / P.V. Mohanan, editor.
Mohanan, P. V., editor.
2022
R856
Available Online

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Title Microfluidics and multi organs on chip / P.V. Mohanan, editor.
ISBN 9789811913792 (electronic bk.)
981191379X (electronic bk.)
9789811913785
9811913781
DOI https://doi.org/10.1007/978-981-19-1379-2
Publication Details Singapore : Springer, 2022.
Language English
Description 1 online resource (ix, 717 pages) : illustrations.
Item Number 10.1007/978-981-19-1379-2 doi
Call Number R856
Dewey Decimal Classification 610.28
Summary This book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed July 25, 2022).
Added Author Mohanan, P. V., editor.
Available in Other Form Microfluidics and Multi Organs on Chip.
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Historical and technological background to 'organ on a chip'
Applications of microfluidics
Microfluidics-based organ-on-a-chip for cell biology studies
Microfluidics in chemical biology
Role of microfluidics in drug delivery
Microfluidics in drug delivery
Microfludic-based sensors
Background and organ on a chip
Culture and co-culture of cells for multi-organ on a chip
Cells and organs on a chip in biomedical sciences
Futuristic aspects of human organ on a chip
Development of Human-on-a-chip
Multiorgans-on-a-chip for personalized medicine
Development and application of microfluidicss in organoid formation
Liver-on-a-chip
Placenta on chip : a modern approach to probe feto-maternal interface
Microfluidic retina-on-chip
Heart-on-a-chip
Kidney-on-a-chip
Lung-on-a-chip
Brain-on-a-chip
Skin-on-chip
Organs-on-a-chip in preclinical studies
Application of organ-on-chip in blood brain barrier model
Multi-organs-on-a-chip in disease modelling
Prospects of medical-device-on-a-chip
Lab-on-a-chip for functional testing for precision medicine
Tumour-on-a-chip : perfusion systems to model the extracellular breast tumour microenvironment - from tumour progression to metastasis formation
Building human in vitro 3D models to replace animal studies : during drug discovery research : scientific, ethical and regulatory considerations.

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