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Part I. Fundamentals of COVID-19
Introduction and Essential multi-organs pathophysiology
Part II. Pneumological critical care of COVID-19
Pathophysiology and phenotypes
Radiological patterns and lung ultrasound
Noninvasive mechanical ventilation and conventional oxygen therapy
Criteria for intubation and ICU admission
Invasive mechanical ventilation
Weaning, tracheostomy and chest physiotherapy
Part III. Neurological manifestations of COVID-19
Brief pathophysiology
Clinical characteristics
Role of noninvasive neuro-monitoring systems and imaging
Biomarkers
Management of neurological complications
Part IV. Cardiovascular manifestations of COVID-19
Brief pathophysiology
Echocardiography, electrocardiogram and biomarkers
Clinical characteristics
Management
Part V. Renal manifestations of COVID-19
Brief pathophysiology
Clinical features and biomarkers
Renal replacement therapy
Part VI. Haemostasis and coagulation in COVID-19
Brief pathophysiology
Coagulation disorders and management
Part VII. Other multi-organs involvement (MODS-CoV-2)
Gastrointestinal manifestations (including hepatic disease)
Nutritional therapy
Part VIII. Principles of therapy
Sedation, analgesia, myorelaxants
Antibiotics, antiretroviral, corticosteroids, other therapies against SARS-CoV-2
Coagulation and haemostasis
Rescue therapies
Part IX. Appendix - Practical Aspects (Figures and Flowcharts).

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