Intro
Preface
Contents
ADHD in Children and Adults: Diagnosis and Prognosis
1 Introduction
2 Diagnosis
3 ADHD in Preschool Children
4 ADHD in School-Aged Children
5 ADHD in Adolescents
6 ADHD in Adults
7 Conclusion
References
Current Pharmacological Treatments for ADHD
1 Introduction
2 Medications for ADHD and Their Mechanism of Action
2.1 Stimulant Medications
2.1.1 Methylphenidate
2.1.2 Amphetamine
2.2 Nonstimulants
2.2.1 Atomoxetine
2.2.2 Guanfacine and Clonidine
3 Pharmacokinetics of ADHD Medications

4 ADHD Medications and the Cognitive Neuroscience of ADHD
5 Efficacy and Tolerability: Comparison Between Medications
6 Effects of ADHD Medications on Other Outcomes and Comorbidities
7 Factors to Consider When Choosing Treatments
8 Conclusions
References
The Benefits and Limitations of Stimulants in Treating ADHD
1 Introduction
2 Stimulants Used to Treat ADHD
3 Political, Ethical, and Moral Issues Relating to the Use of Stimulants for the Treatment of ADHD
4 The Treatment of Subsyndromal ADHD and the Use of Stimulants as Cognitive Enhancers

5 Comparative Efficacy Between Stimulants and Non-pharmacological Treatments for ADHD
6 Comparative Efficacy, Effectiveness, and Safety of Pharmacological Treatments for ADHD
6.1 Children and Adolescents
6.2 Adults
6.3 Comparisons Between Different Stimulant Formulations
7 Clinical Implications of These Findings
8 Monitoring Treatment Response and the Potential Benefits of Integrating Measurement-Based Care Approaches into Clinical Prac ...
9 Do Stimulants Work and Are They Safe Over the Long Term?
10 Considerations for Different Clinical Populations

11 Summary and Conclusions
References
New Drugs to Treat ADHD: Opportunities and Challenges in Research and Development
1 Introduction
2 Current Status of Drugs to Treat ADHD
3 Non-clinical and Clinical Pharmacology of Approved Drugs to Treat ADHD
3.1 Lisdexamfetamine
3.2 Viloxazine
3.3 Prodrugs for Methylphenidate
3.4 Comment (Summary/Overview)
4 Update on the Progress of R & D in the Search for New Drugs to Treat ADHD
4.1 Centanafadine
4.2 Mazindol
4.3 Dasotraline
4.4 Vortioxetine
4.5 Droxidopa
4.6 Baicalin
4.7 Summary

5 Progress in the Pharmacological Management of ADHD
5.1 Efficacy in ADHD
5.2 Once-Daily Medication
5.3 Relapse on Withdrawal
5.4 Drug-Induced Side Effects
5.5 Abuse Liability
6 The Link Between ADHD and Binge-Eating Disorder
7 Concluding Remarks
References
Effects of Methylphenidate on the Dopamine Transporter and Beyond
1 Introduction
2 Methylphenidate and the Central Catecholamine Systems
2.1 Methylphenidate and the Catecholamine Transporters
2.2 Methylphenidate and Other Catecholamine Protein Targets