Intro
Preface
Contents
Part I: Anhedonia
History, Etiology, and Assessments
Clinical and Preclinical Assessments of Anhedonia in Psychiatric Disorders
1 Introduction
2 Clinical Scales of Anhedonia and Reward Deficits: Beyond Pleasure and Interest
2.1 Early Measures (1970-2000)
2.2 Contemporary Measures (2001-2021)
2.3 Other Measures of Anhedonia
2.4 Gaps in Existing Anhedonia Clinical Scales
3 Preclinical and Clinical Reward Tasks
3.1 Anticipation
3.1.1 Preclinical
3.1.2 Clinical
3.2 Motivation and Effort Expenditure
3.2.1 Preclinical

3.2.2 Clinical
3.3 Valuation of Reward
3.3.1 Preclinical
3.3.2 Clinical
3.4 Expectation and Prediction Error
3.4.1 Preclinical
3.4.2 Clinical
3.5 Outcome and Consummatory Pleasure
3.5.1 Preclinical
3.5.2 Clinical
3.6 Reward Learning and Feedback Integration
3.6.1 Preclinical
3.6.2 Clinical
3.7 Translational Difficulties in Behavioral Assessments of Anhedonia
4 Conclusions
References
Developmental Trajectories of Anhedonia in Preclinical Models
1 The Concept of Anhedonia and Its Operationalization in Preclinical Models

1.1 Novel Tools for the Study of Anhedonia in Preclinical Models
1.2 The Reward Circuit and Its Study in Experimental Models
2 Anhedonia and Early-Life Adversity (ELA)
2.1 Why Study ELA and Anhedonia? The Human Landscape
2.2 What Is ELA and How Do We Model It?
2.3 Anhedonia Following ELA Involves a Developing Reward Circuit
2.4 Anhedonia After ELA: Manifestations and Sex Specificity
3 General Conclusions
References
Origins of Anhedonia in Childhood and Adolescence
1 Introduction
2 Impact of Positive Caregiving During Infancy

3 Impact of Memory Processes and Social Engagement During Early and Middle Childhood
4 Role of Self-Concept Development During Childhood and Adolescence on Anhedonia
5 Conclusions and Future Directions
References
Understanding Anhedonia from a Genomic Perspective
1 Introduction
2 Contemporary Psychiatric Genetics Frameworks: Relevance to RDoC
3 Genetic Studies of Anhedonia and Related Constructs
3.1 Twin and Family Studies
3.2 Candidate Gene Studies
3.3 GWAS
3.4 Polygenic Studies
4 Conclusions and Future Directions
References

Environmental Contributions to Anhedonia
1 Introduction
2 Definitional Issues: Consummatory vs. Motivational Anhedonia
3 Definitional Issues: Stress Exposure and Response
4 Relation of Stress to Reward Processing in the Preclinical Literature
4.1 Chronic Mild Stress
4.2 Acute Stress
4.3 Social Stress
4.4 Maternal Separation
4.5 Stress Response and Reward
4.6 Summary
5 Relation of Stress to Reward Processing in Humans
5.1 Proximal Stressful Life Events
5.2 Early Adversity and Maltreatment
5.3 Acute Laboratory Stress
5.4 Stress Response and Reward