Musculoskeletal ultrasound-guided regenerative medicine / Yasser El Miedany, editor.
El Miedany, Yasser, editor.
2022
R857.T55
Available Online

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Title Musculoskeletal ultrasound-guided regenerative medicine / Yasser El Miedany, editor.
ISBN 9783030982560 (electronic bk.)
3030982564 (electronic bk.)
9783030982553
3030982556
DOI https://doi.org/10.1007/978-3-030-98256-0
Imprint Cham : Springer, 2022.
Language English
Description 1 online resource (554 pages)
Other Standard Identifiers 10.1007/978-3-030-98256-0 doi
Call Number R857.T55
Dewey Decimal Classification 616.02/7
Summary The book examines recent developments in regenerative medicine and the use of musculoskeletal ultrasound. Musculoskeletal regeneration has become a prominent research topic, no doubt due to the sociological and economic pressures imposed by the current ageing population. The ever expanding role of regenerative medicine and the identification as well as characterization of stem cells have introduced a major paradigm shift in the field of musculoskeletal and sports medicine as well as orthopaedic surgery. Whereas in the past, diseased tissue was replaced with allograft material, current trends in research revolve around regenerating damaged tissue. Specifically, regenerative medicine stands in contrast to the standard treatment modalities which impair the bodys natural abilities to facilitate endogenous repair mechanisms such as anti-inflammatory drugs; or destructive modalities (e.g., radiotherapy, nerve ablation, injections of botulinum toxin) and surgical interventions that permanently alter the functioning of a joint, bone or spine. When compared to other allopathic options (including knee and hip arthroplasty with a 90-day mortality rate of 0.7%), regenerative medicine treatment modalities have a lower incidence of adverse events with a growing body of statistically significant medical literature illustrating both their safety and efficacy. Focusing on the major values of regenerative medicine, this book with its 21 chapters is expected to fill an important void in the current literature. It will take that extra step to guide you in your day to day clinical practice. Featuring contributions from a large international group of leaders in regenerative medicine and musculoskeletal ultrasonography, this book is an authoritative reference for rheumatologists, physiatrists, sonographers, radiologists, physiotherapists and orthopaedic specialists.
Note Part II: Diagnostic and Interventional MSK Ultrasound
Includes index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed August 24, 2022).
Added Author El Miedany, Yasser, editor.
Available in Other Form Musculoskeletal Ultrasound-Guided Regenerative Medicine.
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
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Intro
Foreword
Preface
Contents
Contributors
Part I: Regenerative Medicine
1: Fundamentals and Applications of Regenerative Medicine
Introduction
Standard Forms of Therapy vs. Regenerative Medicine
Standard Pharmacotherapy
Basics of Regenerative Medicine
Local Tissue Metabolic Changes
The Potential of Regenerative Medicine in Achieving Metabolic Balance
The Induction of Self-Regeneration
Phases of the Regenerative Medicine
The Importance of Image Guidance
Fundamentals of Cell Therapies
The Mesodermal Embryonic Stem Cells

Stem Cell-Microenvironment Communication
Existing and New Cell Sources
Standard Interventions for the Treatment of Major Musculoskeletal Diseases and Their Limitations
Osteoarthritis
Osteoporosis
Myopathies
The Convergence of Regenerative Medicine and Rehabilitation
Transforming Healthcare Through Regenerative Medicine
Controversies in Regenerative Medicine
Ethics in Musculoskeletal Regenerative Medicine
Regenerative Medicine Curriculum for Next-Generation Physicians
Maturity of the Regenerative Medicine Field
References

2: Regenerative Options for Musculoskeletal Disorders
Introduction
Basic Science of Orthobiologics
Selected Orthobiologics to Treat Primary MSK Conditions
Rotator Cuff Tendinopathy
Lateral Epicondylitis
KOA
Orthobiologics to Augment Current Orthopedic Surgical Procedures
Rotator Cuff Tears
ACL Tears
Meniscal Tears
Cartilage Repairs
Quantifying Outcomes of Orthobiologics
Future of Orthobiologics
Bibliography
3: The Nuts and Bolts of Regenerative Medicine as It Pertains to the Joint
Articular Cartilage

Ligaments and Tendons and Their Effects on Joint Problems
Platelet-Rich Plasma (PRP)
Macrophages: A Secret Weapon in a PRP
Matrix Metalloproteases (MMP) A2M
Stem Cells: The Drivers of Regeneration
Some Generalities
Stem Cell Niche
What Are the Major Stem Cells
Embryonic Stem Cells
Induced Pluripotent Stem Cells (IPS CELLS)
Multilineage-Differentiating Stress-Enduring Cells (Muse Cells)
Very Small Embryonic-Like Stem Cells (V Cells)
Mesenchymal Stem Cells
MSCs Sources
Hematopoietic Stem Cells
Techniques for Obtaining HSCs From Bone Marrow

What Cell Combinations Seem to Work Best for the Joint?
Avascular Necrosis and Ligamentous Problems
Why Does There Seem to Be Differences in Success Between Different Joints?
What Else Is Used to the Stem Cell Procedures for Better Efficiency?
Extracorporeal Shock Wave Therapy (ESWT)
Hyperbaric Oxygen Therapy
Photoactivation of PRP and Stem Cells
Prolotherapy
Ozone Therapy
Allogenic Cell Products
Cytokine Therapy
Stem Cell Ageing Pathways May Be the Key to Regenerative Success
Senescent Cells
Supplements to Increase Success
Citations
Suggested Reading

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