Cardiovascular signaling in health and disease / Narasimham L. Parinandi, Thomas J. Hund, editors.
Parinandi, Narasimham L., editor.; Hund, Thomas J., editor.
2022
RC669
Available Online

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Title Cardiovascular signaling in health and disease / Narasimham L. Parinandi, Thomas J. Hund, editors.
ISBN 9783031083099 (electronic bk.)
3031083091 (electronic bk.)
9783031083082
3031083083
DOI https://doi.org/10.1007/978-3-031-08309-9
Published Cham : Springer, [2022]
Copyright ©2022
Language English
Description 1 online resource (xviii, 527 pages) : illustrations (some color)
Item Number 10.1007/978-3-031-08309-9 doi
Call Number RC669
Dewey Decimal Classification 616.1/071
Summary This contributed volume focuses on cardiovascular diseases (CVDs), and explores the ways in which signaling mechanisms at the biochemical, molecular, and cellular levels in the blood vessels (vascular) and heart contribute to the underlying causes of development and progression of the CVDs. This volume covers unique topics such as oxidant signaling in vascular and heart diseases and health, cytoskeletal signaling in vascular health and disease, phospholipase signaling in CVDs, lipid signaling in vascular and myocardial health and diseases, and drug discovery in cellular signaling for cardiovascular diseases. This book assembles the most important discoveries made by leaders on the cellular signaling mechanisms operating behind the development and progression of life-threatening CVDs. It is an extremely useful resource for the investigators in the field of CVDs, and opens the discussion for further discovery of efficient management and effective treatment of the CVDs.
Note Includes index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed October 6, 2022).
Added Author Parinandi, Narasimham L., editor.
Hund, Thomas J., editor.
Available in Other Form Cardiovascular signaling in health and disease.
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Record Appears in Online Resources > Ebooks
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Intro
Preface on the Current Trends in Cardiovascular Signaling in Health and Disease
Calcium- and Stress-Dependent Signaling in Cardiac Myocytes
Reactive Oxygen Species and Lipid Signaling in Cardiac Myocytes
Inflammatory Signaling, Fibrosis, and Cardiac Function
Neural Regulation of Cardiac Rhythm
Reverse Cholesterol Transport in Atherosclerotic Cardiovascular Disease
Progression of the Atherosclerotic Plaque Regression
Role of Bioactive Lipid, Phosphatidic Acid in Statin-Induced Myotoxicity
Cell-to-Cell Communication in the Vascular Endothelium

The Bioactive Phospholipid, Lysophosphatidic Acid Regulates Vascular Endothelial Barrier Integrity
Role of Lipid Mediators in Regulation of Vascular Endothelial Barrier Integrity and Function
Role of Iron in Diabetic Vascular Endothelial Dysfunction
Acknowledgments
Contents
Authors Biography
Part I: Cardiac Signaling
Calcium-Dependent Signaling in Cardiac Myocytes
Introduction
Physiology
Pathophysiology
Heart Failure
Arrhythmias
Ca-Dependent CaMKII Signaling in the Cardiac Myocyte
Background

Ca-Dependent CaMKII Signaling in Cardiac Myocyte Function and Disease
CaMKII Structure and Ca-Dependent Activation
Posttranslational Modifications of CaMKII as Novel Mechanisms of Cardiac Disease
Cardiac Myocyte Remodeling and Ultrastructural Change
Background
Ultrastructural (T-Tubule) Remodeling
RyR Remodeling
Consequence of Structural Remodeling on Spatiotemporal Factors of Ca Release
Potential Treatments
Conclusions and Research Frontiers
Spatial and Temporal Heterogeneity of Ca-Dependent Signaling
Considerations for Therapy
References

Ankyrin-Spectrin Microdomains in Cardiovascular Diseases
Caveolae Microdomains in Calcium Signaling and Stress Response
Organization of Caveolae Microdomains in Cardiomyocytes
Caveolae-Related Organization of Calcium Signaling
Caveolae, Calcium Signaling, and Disease
Conclusions and Future Perspectives
References
Stress Kinase Signaling in Cardiac Myocytes
Introduction
Stress Kinase MAPK Signaling in the Heart
JNK
P38
ERK
MAPKs and Calcium Homeostasis in Myocytes
Normal and Abnormal Calcium (Ca2+) Signaling in Myocytes

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