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Table of Contents
Introduction (Moray J Campbell & Charlotte L Bevan)
Overview (Jason Carroll)
Part I: Reproduction and Development
Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson)
Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders)
Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh)
Part II: Metabolism
Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm)
Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni)
Part III: Central Systems
Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman)
Chapter 7. Physiological convergence and antagonism between GR and PPAR in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky)
Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray)
Chapter 9. Vitamin D and gut health (James C Fleet)
Part IV: Cancer
Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn)
Chapter 11. AR structural variants and prostate cancer (Laura Cato)
Chapter 12. ER and inflammation (Linnea Hases, Amena Archer & Cecilia Williams)
Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell)
Part V: New developments in transcriptional control by nuclear receptors
Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil)
Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart)
Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan)
Part VI: Clinical Translation
Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe)
Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar)
Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki)
Index.
Overview (Jason Carroll)
Part I: Reproduction and Development
Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson)
Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders)
Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh)
Part II: Metabolism
Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm)
Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni)
Part III: Central Systems
Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman)
Chapter 7. Physiological convergence and antagonism between GR and PPAR in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky)
Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray)
Chapter 9. Vitamin D and gut health (James C Fleet)
Part IV: Cancer
Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn)
Chapter 11. AR structural variants and prostate cancer (Laura Cato)
Chapter 12. ER and inflammation (Linnea Hases, Amena Archer & Cecilia Williams)
Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell)
Part V: New developments in transcriptional control by nuclear receptors
Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil)
Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart)
Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan)
Part VI: Clinical Translation
Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe)
Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar)
Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki)
Index.