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Table of Contents
Intro
Preface
Contents
About the Editor
Contributors
Part I: Therapeutic Implications of Natural Compounds
1 Elimination of Senescent Cells by Polyphenols and Flavonoids
Introduction
Cellular Senescence
Markers of Cellular Senescence
Senescence-Associated Mitochondrial Dysfunction (SAMD)
Senescence-Associated Secretory Phenotype (SASP)
Bystander Effect
Therapy-Induced Senescence (TIS)
TIS Induced by Polyphenols
Escape From TIS
Senescent Cells: A Survival Niche Generating a Complex Tumor Environment
Importance of TIS by the Example of Radiotherapy-Induced Senescence
Role of TIS in Other Cancer Treatments
Polyphenols Inhibiting SASP (Senostatics)
Apigenin
Epigallocatechin-3-Gallate (EGCG)
Resveratrol
Quercetin
Polyphenols as Senolytics (Polyphenols Killing Senescent Cells)
Fisetin
Quercetin
Epigallocatechin-3-Gallate (EGCG)
Curcumin
Herbal Extracts with Senolytic and Senomorphic Properties
Extract of the Plant Solidago virgaurea Subsp. alpestris
Alcoholic Extract of Ajuga taiwanensis
Pinellia ternata Tuber
Olive Plant
Conclusion
References
2 Natural Dietary Alkaloids and Its Synthetic Derivatives as Oxidative Stress-Inducing Agents for Cancer Therapy
Introduction
Berberine
Piperine
Neferine
Piperlongumine
Conclusion
References
3 Natural Therapeutic Strategies for Modulating Oxidative Stress in Cancer
Introduction
Oxidative Stress and Carcinogenesis
Antioxidant Defense Mechanism
Oxidative Stress and Natural Compounds
The Role of Antioxidant Potential of Phytochemicals in Oxidative Stress
Mechanism of Natural Compounds in Combination with Chemotherapy
Marine Product with Antioxidative Stress Activity
Microbial Antioxidative Stress Compounds
Conclusion
Future Perspective
References
4 Antioxidant in Cancer
Introduction
Reactive Oxygen Species (ROS)
Reactive Oxygen Species (ROS) in Cancer
Antioxidants
Antioxidants Types
Defense Mechanism of Antioxidant
Antioxidant: Preventer of Cancer
Antioxidant: Promoter of Cancer
Antioxidant: An Achilles ́Heel
The Antioxidant Conundrum: Friend or Foe
Conclusion
References
5 Antioxidant Activity of Phytochemicals in Cancer
Introduction
Role of Reactive Oxygen Species (ROS) in Cancer Progression
ROS and Chemoresistance Development
Cellular Redox System and Molecular Mechanisms Against ROS
Phytochemicals and Their Antioxidant Activity in Cancer
Triphala
Resveratrol
Indole-3 Carbinol (I3C)
Peucedanum Chenur
Astaxanthin
Quercetin
Ellagic Acid
Caryophyllene Sesquiterpenes
Phlorotannins
The Antioxidant/Pro-oxidant Enigma of Cancer Therapy
Phytochemicals as Immunotherapy Adjuvants
Conclusion and Future Perspectives
References
Preface
Contents
About the Editor
Contributors
Part I: Therapeutic Implications of Natural Compounds
1 Elimination of Senescent Cells by Polyphenols and Flavonoids
Introduction
Cellular Senescence
Markers of Cellular Senescence
Senescence-Associated Mitochondrial Dysfunction (SAMD)
Senescence-Associated Secretory Phenotype (SASP)
Bystander Effect
Therapy-Induced Senescence (TIS)
TIS Induced by Polyphenols
Escape From TIS
Senescent Cells: A Survival Niche Generating a Complex Tumor Environment
Importance of TIS by the Example of Radiotherapy-Induced Senescence
Role of TIS in Other Cancer Treatments
Polyphenols Inhibiting SASP (Senostatics)
Apigenin
Epigallocatechin-3-Gallate (EGCG)
Resveratrol
Quercetin
Polyphenols as Senolytics (Polyphenols Killing Senescent Cells)
Fisetin
Quercetin
Epigallocatechin-3-Gallate (EGCG)
Curcumin
Herbal Extracts with Senolytic and Senomorphic Properties
Extract of the Plant Solidago virgaurea Subsp. alpestris
Alcoholic Extract of Ajuga taiwanensis
Pinellia ternata Tuber
Olive Plant
Conclusion
References
2 Natural Dietary Alkaloids and Its Synthetic Derivatives as Oxidative Stress-Inducing Agents for Cancer Therapy
Introduction
Berberine
Piperine
Neferine
Piperlongumine
Conclusion
References
3 Natural Therapeutic Strategies for Modulating Oxidative Stress in Cancer
Introduction
Oxidative Stress and Carcinogenesis
Antioxidant Defense Mechanism
Oxidative Stress and Natural Compounds
The Role of Antioxidant Potential of Phytochemicals in Oxidative Stress
Mechanism of Natural Compounds in Combination with Chemotherapy
Marine Product with Antioxidative Stress Activity
Microbial Antioxidative Stress Compounds
Conclusion
Future Perspective
References
4 Antioxidant in Cancer
Introduction
Reactive Oxygen Species (ROS)
Reactive Oxygen Species (ROS) in Cancer
Antioxidants
Antioxidants Types
Defense Mechanism of Antioxidant
Antioxidant: Preventer of Cancer
Antioxidant: Promoter of Cancer
Antioxidant: An Achilles ́Heel
The Antioxidant Conundrum: Friend or Foe
Conclusion
References
5 Antioxidant Activity of Phytochemicals in Cancer
Introduction
Role of Reactive Oxygen Species (ROS) in Cancer Progression
ROS and Chemoresistance Development
Cellular Redox System and Molecular Mechanisms Against ROS
Phytochemicals and Their Antioxidant Activity in Cancer
Triphala
Resveratrol
Indole-3 Carbinol (I3C)
Peucedanum Chenur
Astaxanthin
Quercetin
Ellagic Acid
Caryophyllene Sesquiterpenes
Phlorotannins
The Antioxidant/Pro-oxidant Enigma of Cancer Therapy
Phytochemicals as Immunotherapy Adjuvants
Conclusion and Future Perspectives
References