Opioids : pharmacology, abuse, and addiction / Silvia L. Cruz, editor.
Cruz, Silvia L., editor.
2022
RM328
Available Online

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Title Opioids : pharmacology, abuse, and addiction / Silvia L. Cruz, editor.
ISBN 9783031099366 (electronic bk.)
3031099362 (electronic bk.)
9783031099359
3031099354
DOI https://doi.org/10.1007/978-3-031-09936-6
Published Cham : Springer, [2022]
Copyright ©2022
Language English
Description 1 online resource (xv, 387 pages) : illustrations (chiefly color)
Item Number 10.1007/978-3-031-09936-6 doi
Call Number RM328
Dewey Decimal Classification 615.7/83
Summary Opioids are the mainstay in pain treatment and can be invaluable medications in palliative care. However, they are also responsible for the vast majority of preventable deaths related to drug use. This book presents an overview of the social and pharmacological aspects of opioid effects, aiming to provide researchers and health professionals with a firm understanding of their effects and mechanisms of action. The first section reviews the history of opioids from ancient civilizations to the current opioid crisis, gives voice to opioid users through first-hand testimonies, analyzes the existing international drug treatment agreements, and presents structured interventions for persons who misuse opioids. The second section covers state-of-the-art advances in the medical use of opioids, opioid-induced signal transduction, opioids in pain management, opioid use disorders and their treatment. It also presents an updated view of opioids as regulators of inflammation and host defense against pathogens and damage. The overall aim of this book is to provide the reader with a deeper knowledge of this field despite the complexities associated with the existence of numerous ligands, receptor subtypes, and complex pharmacological profiles. To this end, the chapter authors are specialists in the field who also have extensive experience in teaching, hoping to lend their expertise in translating complex concepts into comprehensive and clear explanations.
Note Includes index.
Bibliography, etc. Note References -- Chapter 2: The Two Sides of Opioid Use: Unmet Needs of Opioids for Pain Management and the Role of Opioids in Substance Use Disorders -- 2.1 Introduction -- 2.1.1 Background -- 2.2 Drug Markets -- 2.2.1 Unregulated Markets -- 2.2.2 Regulated Markets -- 2.3 Opioids for Pain Management -- 2.3.1 Pain Treatment Needs -- 2.3.2 Disparities in the Availability of Pain Medication -- 2.4 The Global Opioid Problem -- 2.4.1 Stigma, Discrimination, and Human Rights -- 2.4.2 Opioid Agonist Therapy (OAT) -- 2.5 Recommendations -- References -- Chapter 3: Opioid Markets and Special Populations
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed October 19, 2022).
Added Author Cruz, Silvia L., editor.
Available in Other Form Print version: 9783031099359
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
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Intro
Preface
Introduction
Part I: Social Aspects of Opioid Use
Part II: Pharmacological and Medical Aspects of Opioid Use
Contents
About the Editor
Part I: Social Aspects of Opioid Use
Chapter 1: A Brief History of Opioids and the Evolution of Concepts Associated with Substance Use Disorders
1.1 Origins of the Poppy Flower and the Use of Opium in Ancient Civilizations
1.2 Expansion of Opioid Use in the Middle Ages
1.3 From Opium Dens in Asia to Europe
1.3.1 Opium Use in India
1.3.2 Opium Use in China
1.3.3 The Opium Wars

1.4 Opium and Morphine Use in the Western: Laudanum, Dover's Powder, and Soothing Syrups
1.5 From Morphine Isolation to Opioid Use Restriction
1.5.1 The Isolation of Morphine
1.5.2 The Hypodermic Needle and Heroin Synthesis
1.5.3 The Harrison Narcotics Tax Act
1.6 Synthetic Opioids, Opioid Receptors, and the Discovery of Endogenous Opioid Peptides
1.6.1 Opioid Synthesis
1.6.2 Opioid Receptor Subtypes
1.6.3 Endogenous Opioid Peptides
1.7 Opioids in the Context of Globalization
1.8 Evolution of Concepts Associated with Substance Use Disorders
1.9 Conclusions

3.1 Introduction
3.1.1 Opioid Use
3.1.2 Epidemiology of Opioid Use Disorders (OUDs)
3.2 Vulnerability According to Age Groups and Gender
3.2.1 Drug Use Among Women
3.2.2 Young People
3.2.3 Older Adults
3.3 Consequences of Opioid Use
3.3.1 Prenatal Exposure
3.3.2 Children and Adolescents
3.4 Challenges for the Treatment of OUDs
3.5 Supply
3.5.1 Legal and Illegal Markets
3.5.2 Production and Traffic (Wholesaler Versus Retailer)
3.6 Market Characteristics
3.6.1 Combined Use of Opioids with Other Drugs

3.6.2 Indiscriminate Use of Prescription Opioid Analgesics
3.7 Drugs, Crime, and Violence
3.8 Mexico-The United States: A Complex Bilateral Relationship
3.9 Demand
3.10 Impact of COVID-19 on Opioid Supply and Demand
3.11 Future Challenges: Interventions and the Future of Market Regulation
References
Chapter 4: Toward a New Drug Policy Agreement
4.1 International Drug Control: Origins and Characteristics
4.1.1 First Steps in the Establishment of an International Drug Control System
4.1.2 The League of Nations in the International Drug Control Regime

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