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Neuroscience in the 21st century : from basic to clinical / Donald W. Pfaff, Nora D. Volkow, John L. Rubenstein, editors.

Pfaff, Donald W., 1939- editor.; Volkow, Nora D., 1956- editor.; Rubenstein, John L. R., 1955- editor.
2022
RC341
Available Online
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Title
Neuroscience in the 21st century : from basic to clinical / Donald W. Pfaff, Nora D. Volkow, John L. Rubenstein, editors.
Edition
Third edition.
ISBN
9783030888329 (electronic bk.)
3030888320 (electronic bk.)
9783030888312
3030888312
DOI
https://doi.org/10.1007/978-3-030-88832-9
Published
Cham : Springer, [2022]
Copyright
©2022
Language
English
Description
1 online resource (lix, 4,638 pages) : illustrations (some color)
Item Number
10.1007/978-3-030-88832-9 doi
Call Number
RC341
Dewey Decimal Classification
612.8
Summary
Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimers and other dementias. Because neuroscience takes the etiology of diseasethe complex interplay between biological, psychological, and sociocultural factorsas its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21stCentury in its third edition serves as a comprehensive resource to students and researchers alike.
Note
Includes index.
Access Note
Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed October 31, 2022).
Added Author
Pfaff, Donald W., 1939- editor.
Volkow, Nora D., 1956- editor.
Rubenstein, John L. R., 1955- editor.
Available in Other Form
Print version: 9783030888312
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Intro
Preface to the Third Edition
Neuroscience Addresses Medical and Public Health Problems, Worldwide
Preface to the Second Edition
Neuroscience Addresses Medical and Public Health Problems, Worldwide
Preface to the First Edition
Neuroscience Addresses Medical and Public Health Problems, Worldwide
Further Reading
Editors-in-Chief
Supervisory Editors
Contents
Contributors
Part I: Basic Neuroscience: Biophysics
1 Voltage-Gated Ion Channels
Brief History
Introduction
Voltage-Gated Ion Channels are Multimeric Protein Complexes

Changes in the Conformation of the Pore-Forming Subunits Determine the State of the Channel
VGSC States and Na+ Current Properties
Modulation of Voltage-Gated Ion Channels Function
Abnormalities in Voltage-Gated Ion Channel Functions Can Result in Human Disease
Voltage-Gated Ion Channels are Targets of Therapeutic Agents
Outlook
Cross-References
References
2 Water, Ions, Membranes, Pumps, and Transporters
Brief History
Water
Water as a Solvent
Membranes
Pumps and Pores
The Resting Membrane Potential
Electrical Models of the Cell Membrane

Homeostasis Versus Electrical Excitability
Outlook
Glossary
References
3 Ionotropic Glutamate Receptors (and Their Role in Health and Disease)
Brief History
Why Does the Brain Need Ligand-Gated Ion Channels?
From the Primary to the 3D Structure of Ionotropic Glutamate Receptors
Primary Structure
Secondary Structure
3D Structure
The Physiological Function of Ionotropic Glutamate Receptors in Rodents
Primary Function
Orphan Receptors
Kainate Receptors
AMPA Receptors
NMDA Receptors
AMPA and NMDA Receptors in Learning and Memory

The NMDA Receptor Function of Coincidence Detection in Learning
Function of AMPA and NMDA Receptors in the Behavior of Experimental Animals
NMDA Receptor Dysfunction During Development
NMDA Receptor Hypofunction
NMDA Receptor Hyperfunction
Conditional NMDA Receptor Knockouts
AMPA Receptor Gene-Targeted Mice
AMPA and NMDA Receptor Dysfunction in CNS Disorders
Auxiliary Subunits of iGluRs
AMPA and NMDA Receptor Interactors in the Postsynaptic Density
Outlook
Cross-References
References
4 Signal Transduction-Dependent Channels
Brief History
Introduction

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