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Table of Contents
Intro
Preface
Contents
Contributors
Part I: Biology and Evolution of Pseudomonas aeruginosa
1: Pseudomonas aeruginosa Pangenome: Core and Accessory Genes of a Highly Resourceful Opportunistic Pathogen
1.1 Pseudomonas aeruginosa Environment and Main Genomic Characteristics
1.1.1 Pangenomics and Populations Structure Analyses in Population Genomics
1.2 The Population Structure of Pseudomonas aeruginosa
1.3 The Pangenome of Pseudomonas aeruginosa
1.3.1 Characterization of the Core Genome of Pseudomonas aeruginosa
1.3.2 Comparison of Antibiotic Resistance Profiles Among Phylogroups of Pseudomonas aeruginosa Species
1.4 The Highly Variable Accessory Genome of Pseudomonas aeruginosa
1.5 Conclusions
References
2: Iron Homeostasis in Pseudomonas aeruginosa: Targeting Iron Acquisition and Storage as an Antimicrobial Strategy
2.1 Introduction
2.2 Iron Acquisition Systems in P. aeruginosa
2.2.1 Production and Utilization of the Endogenous Siderophores Pyoverdine and Pyochelin
2.2.2 Xenosiderophore-Mediated Iron Acquisition
2.2.3 Iron Acquisition from the Host Heme Molecule
2.6.2 Siderophore Signaling by Two-Component Systems
2.6.3 Siderophore Signaling by One-Component Systems
2.7 Other Systems Involved in the Regulation of Iron Homeostasis in P. aeruginosa
2.8 Iron and P. aeruginosa Virulence
2.9 Strategies to Block P. aeruginosa Infections by Disrupting Iron Homeostasis
2.9.1 Neutralization of Siderophores with Lipocalin-Based Proteins
2.9.2 Utilization of Iron Chelators
2.9.3 Utilization of the Iron Mimicking Metal Gallium
2.9.4 Use of Siderophore-Dependent Uptake Systems to Deliver Antimicrobials: The `Trojan-Horse ́Strategy
2.9.5 Other Strategies
References
3: Controlling Biofilm Development Through Cyclic di-GMP Signaling
3.1 Introduction
3.2 The First Contact with the Surface: Timing and Heterogeneity of Contact-Dependent Modulation of c-di-GMP Levels
3.3 Consequences of Surface Contact and Downstream Factors
3.4 Key Players Contributing to Biofilm Maturation
3.5 c-di-GMP Levels and Maintenance of the Mature Biofilm Structure
3.6 Biofilm Dispersion: The Return to Low c-di-GMP Levels
3.7 Turnover and Modulation of the c-di-GMP Pool in Biofilms
3.8 Blocking c-di-GMP for Biofilm Control
Preface
Contents
Contributors
Part I: Biology and Evolution of Pseudomonas aeruginosa
1: Pseudomonas aeruginosa Pangenome: Core and Accessory Genes of a Highly Resourceful Opportunistic Pathogen
1.1 Pseudomonas aeruginosa Environment and Main Genomic Characteristics
1.1.1 Pangenomics and Populations Structure Analyses in Population Genomics
1.2 The Population Structure of Pseudomonas aeruginosa
1.3 The Pangenome of Pseudomonas aeruginosa
1.3.1 Characterization of the Core Genome of Pseudomonas aeruginosa
1.3.2 Comparison of Antibiotic Resistance Profiles Among Phylogroups of Pseudomonas aeruginosa Species
1.4 The Highly Variable Accessory Genome of Pseudomonas aeruginosa
1.5 Conclusions
References
2: Iron Homeostasis in Pseudomonas aeruginosa: Targeting Iron Acquisition and Storage as an Antimicrobial Strategy
2.1 Introduction
2.2 Iron Acquisition Systems in P. aeruginosa
2.2.1 Production and Utilization of the Endogenous Siderophores Pyoverdine and Pyochelin
2.2.2 Xenosiderophore-Mediated Iron Acquisition
2.2.3 Iron Acquisition from the Host Heme Molecule
2.6.2 Siderophore Signaling by Two-Component Systems
2.6.3 Siderophore Signaling by One-Component Systems
2.7 Other Systems Involved in the Regulation of Iron Homeostasis in P. aeruginosa
2.8 Iron and P. aeruginosa Virulence
2.9 Strategies to Block P. aeruginosa Infections by Disrupting Iron Homeostasis
2.9.1 Neutralization of Siderophores with Lipocalin-Based Proteins
2.9.2 Utilization of Iron Chelators
2.9.3 Utilization of the Iron Mimicking Metal Gallium
2.9.4 Use of Siderophore-Dependent Uptake Systems to Deliver Antimicrobials: The `Trojan-Horse ́Strategy
2.9.5 Other Strategies
References
3: Controlling Biofilm Development Through Cyclic di-GMP Signaling
3.1 Introduction
3.2 The First Contact with the Surface: Timing and Heterogeneity of Contact-Dependent Modulation of c-di-GMP Levels
3.3 Consequences of Surface Contact and Downstream Factors
3.4 Key Players Contributing to Biofilm Maturation
3.5 c-di-GMP Levels and Maintenance of the Mature Biofilm Structure
3.6 Biofilm Dispersion: The Return to Low c-di-GMP Levels
3.7 Turnover and Modulation of the c-di-GMP Pool in Biofilms
3.8 Blocking c-di-GMP for Biofilm Control