TY - GEN AB - This book provides a systemic review of the development, function, and role of plasmacytoid Dendritic Cells (pDCs) in human diseases. The chapters of the book discuss the origin and discovery, heterogeneity, development, and transcriptional regulation of pDCs. It also discusses the role of pDCs in human diseases, including cancers, metabolic disorders, and autoimmune/inflammatory diseases, and opportunities for pDCtargeting therapies in these diseases. It also highlights the current understanding of pDC involvement in autoimmunity and alloreactivity and opportunities for pDCtargeting therapies in the disorders. Lastly, it reviews the experimental methodologies and animal models that are used to explore the functions of pDCs. AU - Ganguly, Dipyaman, CN - QR185.8.D45 DO - 10.1007/978-981-19-5595-2 DO - doi ID - 1450552 KW - Dendritic cells. KW - Immunology. LK - https://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-981-19-5595-2 N2 - This book provides a systemic review of the development, function, and role of plasmacytoid Dendritic Cells (pDCs) in human diseases. The chapters of the book discuss the origin and discovery, heterogeneity, development, and transcriptional regulation of pDCs. It also discusses the role of pDCs in human diseases, including cancers, metabolic disorders, and autoimmune/inflammatory diseases, and opportunities for pDCtargeting therapies in these diseases. It also highlights the current understanding of pDC involvement in autoimmunity and alloreactivity and opportunities for pDCtargeting therapies in the disorders. Lastly, it reviews the experimental methodologies and animal models that are used to explore the functions of pDCs. SN - 9789811955952 SN - 9811955956 T1 - Plasmacytoid dendritic cells / TI - Plasmacytoid dendritic cells / UR - https://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-981-19-5595-2 ER -