@article{1450627,
      recid = {1450627},
      author = {Dominguez-Villar, Margarita,},
      title = {PI3K and AKT isoforms in immunity : mechanisms and  therapeutic opportunities /},
      pages = {1 online resource :},
      abstract = {This book provides an essential overview of the role of  phosphoinositide-3-phosphate kinase (PI3K) isoforms in  modulating the function of immune system cells and their  involvement in disease. PI3K is a family of kinases  involved in basic cellular processes such as proliferation,  migration and cell death. Recent work has highlighted the  multiple roles of PI3K classes and subunits and their  involvement in the immune response to the bodys own and  foreign antigens and diseases such as cancer and  autoimmunity. This book offers a detailed introduction to  the biology of the three PI3K classes, followed by an  extensive discussion of the diverse roles of AKT and PI3K  isoforms in immune cells. Based on this knowledge, it  subsequently explains in more detail how specific isoforms  are connected to immune-mediated diseases. The book  concludes by highlighting the latest advances in the  production of isoform-specific inhibitors and their use in  various human diseases. This book is intended as a  reference guide for students and researchers interested in  the multifaceted aspects of PI3K biology.},
      url = {http://library.usi.edu/record/1450627},
      doi = {https://doi.org/10.1007/978-3-031-06566-8},
}