001450627 000__ 03904cam\a2200505\i\4500
001450627 001__ 1450627
001450627 003__ OCoLC
001450627 005__ 20230310004535.0
001450627 006__ m\\\\\o\\d\\\\\\\\
001450627 007__ cr\cn\nnnunnun
001450627 008__ 221025s2022\\\\sz\a\\\\o\\\\\000\0\eng\d
001450627 019__ $$a1347783661$$a1348493504
001450627 020__ $$a9783031065668$$q(electronic bk.)
001450627 020__ $$a3031065662$$q(electronic bk.)
001450627 020__ $$z9783031065651
001450627 020__ $$z3031065654
001450627 0247_ $$a10.1007/978-3-031-06566-8$$2doi
001450627 035__ $$aSP(OCoLC)1348649112
001450627 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dYDX$$dEBLCP$$dOCLCF$$dUKAHL$$dOCLCQ
001450627 049__ $$aISEA
001450627 050_4 $$aQR185.6
001450627 08204 $$a571.9/6$$223/eng/20221025
001450627 24500 $$aPI3K and AKT isoforms in immunity :$$bmechanisms and therapeutic opportunities /$$cMargarita Dominguez-Villar, editor.
001450627 264_1 $$aCham :$$bSpringer,$$c2022.
001450627 300__ $$a1 online resource :$$billustrations (black and white, and color).
001450627 336__ $$atext$$btxt$$2rdacontent
001450627 337__ $$acomputer$$bc$$2rdamedia
001450627 338__ $$aonline resource$$bcr$$2rdacarrier
001450627 4901_ $$aCurrent topics in microbiology and immunology ;$$vvolume 436
001450627 5050_ $$aClass I PI3K biology -- Class II PI3K biology -- Class III PI3K biology -- PTEN in immunity -- PHLPP Signaling in Immune Cells -- PHLPP Signaling in Immune Cells -- PI3K isoforms in cell signalling and innate immune cell responses -- AKT isoforms in macrophage activation, polarization and survival -- Control of CD4+ T cell Differentiation and Function by PI3K isoforms. -- PI3K isoforms in CD8+ T cell development and function -- PI3K isoforms in B cells -- PI3K isoform signalling in platelets -- PI3K isoforms in vascular biology, a focus on the vascular system-immune response connection -- PI3K and AKT at the Interface of Signaling and Metabolism -- The Role of PI3K Isoforms in Autoimmune Disease -- AKT Isoforms in the Immune Response in Cancer -- PI3K isoform immunotherapy for solid tumours -- PI3K targeting in non-solid cancer -- AKT isoforms as a target in cancer and immunotherapy -- Developing PI3K Inhibitors for Respiratory Diseases.
001450627 506__ $$aAccess limited to authorized users.
001450627 520__ $$aThis book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the bodys own and foreign antigens and diseases such as cancer and autoimmunity. This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases. This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.
001450627 588__ $$aDescription based on print version record.
001450627 650_0 $$aMolecular immunology.
001450627 650_0 $$aPhosphoinositides.
001450627 655_0 $$aElectronic books.
001450627 7001_ $$aDominguez-Villar, Margarita,$$eeditor.
001450627 77608 $$iPrint version:$$tPI3K and AKT isoforms in immunity.$$dCham : Springer, 2022$$z9783031065651$$w(OCoLC)1338651949
001450627 830_0 $$aCurrent topics in microbiology and immunology ;$$v436.
001450627 852__ $$bebk
001450627 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-06566-8$$zOnline Access$$91397441.1
001450627 909CO $$ooai:library.usi.edu:1450627$$pGLOBAL_SET
001450627 980__ $$aBIB
001450627 980__ $$aEBOOK
001450627 982__ $$aEbook
001450627 983__ $$aOnline
001450627 994__ $$a92$$bISE