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001450717 001__ 1450717
001450717 003__ OCoLC
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001450717 019__ $$a1349280091
001450717 020__ $$a9783031123986$$q(electronic bk.)
001450717 020__ $$a3031123980$$q(electronic bk.)
001450717 020__ $$z3031123972
001450717 020__ $$z9783031123979
001450717 0247_ $$a10.1007/978-3-031-12398-6$$2doi
001450717 035__ $$aSP(OCoLC)1349085628
001450717 040__ $$aYDX$$beng$$cYDX$$dGW5XE$$dEBLCP$$dOCLCF$$dUKAHL$$dOCLCQ
001450717 049__ $$aISEA
001450717 050_4 $$aRM301.9
001450717 08204 $$a615.9$$223/eng/20221104
001450717 24500 $$aRecent advances in therapeutic drug monitoring and clinical toxicology /$$cSeth Kwabena Amponsah, Yashwant V. Pathak, editors.
001450717 260__ $$aCham, Switzerland :$$bSpringer,$$c2022.
001450717 300__ $$a1 online resource
001450717 500__ $$aIncludes index.
001450717 5050_ $$aIntro -- Foreword -- Preface -- Contents -- About the Editors -- Contributors -- 1: Therapeutic and Toxic Concentrations of Drugs in Biological Matrices -- 1.1 Introduction -- 1.2 Therapeutic Drug Monitoring -- 1.3 Biological Matrices -- 1.3.1 Blood -- 1.3.2 Urine -- 1.3.3 Saliva -- 1.3.4 Cerebrospinal Fluid (CSF) -- 1.3.5 Hair -- 1.4 Therapeutic Concentration of Drugs -- 1.5 Toxic Concentration of Drugs -- 1.6 Conclusion -- References -- 2: Analytical Techniques for Therapeutic Drug Monitoring and Clinical Toxicology -- 2.1 Introduction -- 2.2 Immunoassays
001450717 5058_ $$a2.3 Electrophoresis -- 2.4 Biosensors -- 2.5 Conventional HPLC and Emerging UHPLC Techniques -- 2.6 Gas Chromatography (GC) -- 2.7 Conclusion and Outlook -- References -- 3: Plasma Therapeutic Drug Monitoring and Clinical Toxicology -- 3.1 Overview of Therapeutic Drug Monitoring (TDM) -- 3.1.1 Assumptions -- 3.1.2 Process of Therapeutic Drug Monitoring -- 3.2 Indications for Measuring Plasma Concentrations -- 3.2.1 Avoiding or Diagnosing Toxicity -- 3.2.2 Diagnosing Undertreatment and Monitoring Patient Adherence -- 3.2.3 Prophylaxis
001450717 5058_ $$a3.2.4 Drug Interactions and Termination of Treatment -- 3.3 Proper Use of Measurements -- 3.3.1 Timing of Blood Samples -- 3.3.2 Type of Sample Used -- 3.3.3 Measurement Technique -- 3.3.4 Individualization of Results -- 3.4 Individualizing Therapy -- 3.4.1 Formulation and Diet -- 3.4.2 Pharmacokinetics: Ion Trapping -- 3.4.3 Pathologic Disease States -- 3.4.4 Cytochrome P450 Enzymes -- 3.4.5 Age -- 3.5 Serum Versus Plasma Monitoring -- 3.5.1 Drugs Requiring Monitoring: Digoxin -- 3.5.2 Drugs Requiring Monitoring: Phenytoin
001450717 5058_ $$a3.6 Renal Clearance and Metabolism in Therapeutic Drug Monitoring -- 3.6.1 Critically Ill Patients -- 3.6.2 Geriatric Patients -- 3.6.3 Pediatric Patients -- 3.6.4 Acute or Chronic Renal Failure Patients -- 3.7 Role of Cytochrome P450 Systems in Liver Clearance and Metabolism -- 3.7.1 Acetaminophen -- 3.7.2 Rifampin -- 3.7.3 Erythromycin -- 3.8 Antiretrovirals and Glucose in Therapeutic Drug Monitoring -- 3.8.1 The Role and Influence of Glucose in Therapeutic Drug Monitoring -- 3.8.2 Therapeutic Drug Monitoring of Antiretroviral Drugs -- 3.9 Conclusion -- References
001450717 5058_ $$a4: Dried Blood Spots in Therapeutic Drug Monitoring and Toxicology -- 4.1 Introduction -- 4.2 Therapeutic Drug Monitoring (TDM) -- 4.2.1 DBS in PK Monitoring -- 4.2.2 Factors to Consider in PK Studies Using DBS Sampling -- 4.2.3 Toxicology -- 4.2.3.1 Toxicokinetics -- 4.2.3.2 Forensic Toxicology -- 4.2.3.3 Screening for Environmental Contaminants -- 4.3 The Hematocrit Factor -- 4.3.1 Holistic Analysis of Volumetrically Spotted DBS -- 4.3.2 Use of DPS in Place of DBS -- 4.3.3 Use of Special Filter Substrates -- 4.3.4 Use of Hematocrit Calibrators
001450717 506__ $$aAccess limited to authorized users.
001450717 520__ $$aThis book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges .
001450717 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed November 4, 2022).
001450717 650_0 $$aDrug monitoring.
001450717 650_0 $$aClinical toxicology.
001450717 655_0 $$aElectronic books.
001450717 7001_ $$aAmponsah, Seth Kwabena.
001450717 7001_ $$aPathak, Yashwant Vishnupant.
001450717 77608 $$iPrint version: $$z3031123972$$z9783031123979$$w(OCoLC)1332779924
001450717 852__ $$bebk
001450717 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-12398-6$$zOnline Access$$91397441.1
001450717 909CO $$ooai:library.usi.edu:1450717$$pGLOBAL_SET
001450717 980__ $$aBIB
001450717 980__ $$aEBOOK
001450717 982__ $$aEbook
001450717 983__ $$aOnline
001450717 994__ $$a92$$bISE