Handbook of stem cell therapy. Volume 1 / Khawaja Husnain Haider, editor.
Haider, Khawaja Husnain, editor.
2022
QH588.S83
Available Online

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Title Handbook of stem cell therapy. Volume 1 / Khawaja Husnain Haider, editor.
ISBN 9789811926556 (electronic bk.)
9811926557 (electronic bk.)
9789811926549
9811926549
DOI https://doi.org/10.1007/978-981-19-2655-6
Published Singapore : Springer, [2022]
Copyright ©2022
Language English
Description 1 online resource (xxxi, 1526 pages) : illustrations (chiefly color)
Other Standard Identifiers 10.1007/978-981-19-2655-6 doi
Call Number QH588.S83
Dewey Decimal Classification 616.02/774
Summary The handbook comprehensively reviews the therapeutic potential of stem cells and stem cell secretome-based cell-free strategies in regenerative medicine. The chapters in section I and section II respectively discuss the diverse applications of mesenchymal stem cells and non- mesenchymal stem cells, including skeletal myoblasts, endothelial progenitor cells, adipose tissue-derived stem cells, induced pluripotent stem cells, and neuronal stem cells in myocardial repair, inflammatory bowel disease, cognitive deficits, wound healing, retinal disorders, and COVID-19. The subsequent chapters in section IIIprimarily focused on the fast-emerging cell-free therapy approach in regenerative medicine for tissue repair and regeneration. These chapters review the impact of stem cell-derived secretome on various biological processes such as angiogenesis, neurogenesis, tissue repair, immunomodulation, musculoskeletal pathologies, wound healing, anti-fibrotic, and anti-tumorigenesis for tissue maintenance and regeneration.Lastly, section IV summarizes miscellaneous aspects of cell-based therapy, includingthe treatment advantages, opportunities, and shortcomings in stem cell-based therapy, potentially helping to refine future studies and translate them from experimental to clinical studies. Moreover, this section also has chapters on cancer stem cells as novel targets in cancer therapeutics. This Major Reference Book (MRW) is a valuable resource for researchers involved in stem cell research to understand the multifaceted therapeutic applications of stem cells and their derivative secretome in regenerative medicine.
Note Includes index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed November 22, 2022).
Added Author Haider, Khawaja Husnain, editor.
Available in Other Form Print version: 9789811926549
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Intro
Foreword
Contents
About the Editor
Section Editors
Contributors
Part I: Cell-Based Therapy Approach: Mesenchymal Stem Cell-Based Therapy
1 Human Mesenchymal Stem Cells: The Art to Use Them in the Treatment of Previously Untreatable
Introduction
Mesenchymal Stem Cells Current Status: The ``Problems ́́That in Reality Do Not Exist
Practical Approaches: The Golden Standards, i.e., ``Good Biological Praxis ́́(GBP) Using the Historical Laboratory Experience
Data Extrapolation from Small Animal Studies to Humans Is Unfounded and Without Relevance

Current Research Paradigm: MSCs in Advanced Phases of Clinical Trials Although Understandable Is Far from Personalized Medicine
A Case of Autologous Versus Allogeneic MSCs, an Unanswered Question
A Case for Autologous Cells
Autologous Cells from Patients Are Also ``sick ́́
Autologous Cells in Elderly Patients Are Also Aged
A Case for Allogeneic Cells
Logistic Advantage of Allogenic MSCs
Allogenic MSCs Overcome the Limitations of Aging and Sickness of Autologous Cells
Quality Control of MSCs Preparation: A Prerequisite for Optimal Prognosis
Conclusion
References

2 Sources and Therapeutic Strategies of Mesenchymal Stem Cells in Regenerative Medicine
Introduction
Mesenchymal Stem Cells
Sources of Mesenchymal Stem Cells
Bone Marrow-Derived MSCs
Advantages of BM-Derived MSCs
Limitations of BM-Derived MSCs
Adipose Tissue-Derived MSCs
Advantages of Adipose Tissue-Derived MSCs
Limitations of Adipose Tissue-Derived MSCs
Isolation of Adipose Tissue-Derived MSCs
Clinical Applications of Adipose Tissue-Derived MSCs
Umbilical Cord-Derived MSCs
Human Umbilical Cord Structure and Function
Advantages of WJ-Derived MSCs

Limitations of WJ-Derived MSCs
Isolation Methods of WJ-Derived MSCs
Clinical Applications of WJ-Derived MSCs
Therapeutic Strategies of Using MSCs
Tissue Regeneration
Immunomodulation of MSCs
Extracellular Vesicles/Exosomes Derived from MSCs
MSCs Act as an Efficient Tool for Gene Therapy
References
3 Considerations for Clinical Use of Mesenchymal Stromal Cells
Introduction
Biological Characteristics
Phenotypic Profile
MSCs ́Proliferation
Differentiation Capacity
Cellular Transformation
Mechanism of Action
Cell Migration Toward Damaged Tissues

Tissue Repair
Immunomodulatory Potential
Preclinical Applications
MSC-Based Therapy for Autoimmune Diseases
MSCs for Cancer Treatment
The Anti-tumor Activity of MSCs
The Pro-tumor Activity of MSCs
The Imprint of Disease on MSCs
Considerations for Clinical Applications
Safety Concerns
Cell Manufacturing for Clinical Use
Considerations for Cellular Medicament
General Considerations
Attempts to Improve the Therapeutic Outcomes of Cellular Medicament
Concluding Remarks and Future Perspective
Cross-References
References

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