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001451120 020__ $$a9783031083563$$q(electronic bk.)
001451120 020__ $$a3031083563$$q(electronic bk.)
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001451120 0247_ $$a10.1007/978-3-031-08356-3$$2doi
001451120 035__ $$aSP(OCoLC)1350665668
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001451120 08204 $$a616.99/042$$223/eng/20221116
001451120 24500 $$aSystems biology of microRNAs in cancer /$$cUlf Schmitz, Olaf Wolkenhauer, Julio Vera-González, editors.
001451120 264_1 $$aCham :$$bSpringer,$$c[2022]
001451120 264_4 $$c©2022
001451120 300__ $$a1 online resource (vii, 317 pages) :$$billustrations.
001451120 336__ $$atext$$btxt$$2rdacontent
001451120 337__ $$acomputer$$bc$$2rdamedia
001451120 338__ $$aonline resource$$bcr$$2rdacarrier
001451120 4901_ $$aAdvances in experimental medicine and biology ;$$vvolume 1385
001451120 5050_ $$aIntro -- Contents -- About the Editors -- Chapter 1: The Role of MicroRNAs in Cancer Biology and Therapy from a Systems Biology Perspective -- 1.1 Biological Facts About miRNA Biogenesis and Function -- 1.1.1 miRNA Biogenesis -- 1.1.2 miRNA Function -- 1.2 The Role of miRNAs in Cancer Progression, Diagnosis, and Therapy -- 1.2.1 Genome-Level Alterations in miRNAs -- 1.2.2 Oncogenic and Tumor-Suppressive miRNAs -- 1.2.3 miRNAs in Cancer Diagnostics and Therapy -- 1.3 miRNAs in Cancer Gene Regulatory Networks -- 1.3.1 miRNA Clusters: Groups of Similarly Regulated miRNAs
001451120 5058_ $$a1.3.2 Target Hubs: Genes Regulated by Many miRNAs -- 1.3.3 miRNA Cooperativity: Synergistic Gene Regulation by Multiple miRNAs -- 1.3.4 Network Motifs: miRNA-Enriched Feedback and Feedforward Loops -- 1.4 Bioinformatics and Systems Approaches as the ``Lifeline ́́to Navigate miRNA Networks -- References -- Chapter 2: Circulating MicroRNAs as Cancer Biomarkers in Liquid Biopsies -- 2.1 Introduction -- 2.2 Circulating miRNAs -- 2.3 Function of Circulating miRNAs -- 2.4 Circulating ncRNAs as Cancer Biomarkers -- 2.4.1 MiRNAs -- 2.4.2 LncRNAs and Other ncRNAs
001451120 5058_ $$a2.5 Methods and Challenges to Detect Circulating miRNAs -- 2.6 Bioinformatics Analyses -- 2.6.1 Databases of miRNA: Target RNA Interaction -- 2.6.2 Databases of Transcription Factor: miRNA Gene Interaction -- 2.6.3 Construction of Regulatory Networks -- 2.6.4 Databases of miRNAs with Cancer Biomarker Potential -- 2.6.5 Application of Neural Networks and Meta-Analysis to Identify Robust Biomarkers -- 2.7 Conclusions -- References -- Chapter 3: Regulation of Immune Cells by microRNAs and microRNA-Based Cancer Immunotherapy -- 3.1 Introduction -- 3.2 Innate Immunity -- 3.2.1 Macrophages
001451120 5058_ $$a3.2.2 Dendritic Cells -- 3.2.3 Natural Killer Cells -- 3.3 Adaptive [Acquired] Immunity -- 3.3.1 T-Helper Cells -- 3.3.2 Cytotoxic T Cells -- 3.3.3 Regulatory T Cells -- 3.4 miRNA-Mediated Regulation in the Tumor Microenvironment -- 3.5 Immune Checkpoint Molecules -- 3.6 miRNAs as Potential Targets for Immunotherapy -- 3.7 Challenges in miRNA-Based Therapy -- 3.8 Conclusions -- References -- Chapter 4: Machine Learning Based Methods and Best Practices of microRNA-Target Prediction and Validation -- 4.1 Introduction of miRNAs and Their Role in Cancer -- 4.2 miRNA Target Prediction Tools
001451120 5058_ $$a4.2.1 Common Features for miRNA Target Prediction -- 4.2.2 Machine Learning Based Algorithms for miRNA Target Prediction -- 4.3 Best Practices for miRNA Target Prediction -- 4.3.1 Workflow to Detect miRNA-mRNA Target Sites -- 4.3.2 Validation of miRNA Target Prediction -- 4.4 miRNA-Based Therapeutics for Cancer -- References -- Chapter 5: Turning Data to Knowledge: Online Tools, Databases, and Resources in microRNA Research -- 5.1 Human miRNA Regulation -- 5.2 The Scope and Organization of the Chapter -- 5.3 Repositories for miRNA: Catalogs and Genome Browsers -- 5.3.1 miRNA Gene Catalogs
001451120 506__ $$aAccess limited to authorized users.
001451120 520__ $$aThis book provides an update on the latest development in the field of microRNAs in cancer research with an emphasis on translational research. Since the early 2000s, microRNAs have been recognized as important and ubiquitous regulators of gene expression. Soon it became evident that their deregulation can cause human diseases including cancer. This book focuses on the emerging opportunities for the application of microRNA research in clinical practice. In this context, computer models are presented that can help to identify novel biomarkers, e.g. in circulating microRNAs, and tools that can help to design microRNA-based therapeutic interventions. Other chapters evaluate the role of microRNAs in immunotherapy, immune responses and drug resistance. Covering key topics on microRNAs in cancer research this book is a valuable resource for both emerging and established microRNA researchers who want to explore the potential of microRNAs as therapeutic targets or co-adjuvants in cancer therapies.
001451120 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed November 16, 2022).
001451120 650_0 $$aCancer$$xGenetic aspects$$xResearch.
001451120 650_0 $$aMicroRNA$$xHealth aspects.
001451120 650_0 $$aSystems biology.
001451120 655_0 $$aElectronic books.
001451120 7001_ $$aSchmitz, Ulf,$$eeditor.$$1https://isni.org/isni/0000000410304040
001451120 7001_ $$aWolkenhauer, Olaf,$$d1966-$$eeditor.$$1https://isni.org/isni/0000000114879640
001451120 7001_ $$aVera-González, Julio,$$eeditor.
001451120 77608 $$iPrint version: $$z3031083555$$z9783031083556$$w(OCoLC)1317837901
001451120 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 1385.
001451120 852__ $$bebk
001451120 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-08356-3$$zOnline Access$$91397441.1
001451120 909CO $$ooai:library.usi.edu:1451120$$pGLOBAL_SET
001451120 980__ $$aBIB
001451120 980__ $$aEBOOK
001451120 982__ $$aEbook
001451120 983__ $$aOnline
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