@article{1451143,
      recid = {1451143},
      author = {Zamponi, Gerald W., and Weiss, Norbert,},
      title = {Voltage-gated calcium channels /},
      pages = {1 online resource (ix, 710 pages) :},
      note = {Includes index.},
      abstract = {This book covers the tremendous progress in the current  understanding of the molecular physiology of voltage-gated  calcium channels. This book includes unparalleled insights  into structural features of calcium channels due to X-ray  crystallography and cryo-EM, which in turn yielded critical  information into how these channels function under normal  and pathophysiological conditions, and how they interact  with calcium channel therapeutics. The chapters investigate  how, with the advent of high throughput genome sequencing,  numerous mutations in various calcium channel genes have  been identified in patients with neurological,  cardiovascular, neuropsychiatric and other disorders. This  is further complemented through a much larger in vivo  toolkit such as knock-out and knock-in mice. The chapters  further discuss the increased complexity of calcium channel  physiology that arises from mRNA editing and splicing.  Finally, the book also provides an overview of the updated  research on calcium channel inhibitors that can be used  both in vivo and in vitro, and which may serve as a spring  board for new calcium channel therapeutics for human  disease. Voltage-Gated Calcium Channels is useful for  academic researchers at all levels in neuroscience,  biophysics, cell biology and drug discovery. Provides a  comprehensive update on the state of knowledge of  voltage-gated calcium channels; Examines how calcium  channels are pharmacologic targets in the treatment of  epilepsy, hypertension, and pain; Explores the new,  sophisticated imaging approaches that have increased our  ability to measure calcium in live cells; Presents an  understanding of the molecular mechanisms that govern  calcium channel trafficking and distribution.},
      url = {http://library.usi.edu/record/1451143},
      doi = {https://doi.org/10.1007/978-3-031-08881-0},
}