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001451143 001__ 1451143
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001451143 019__ $$a1350687445
001451143 020__ $$a9783031088810$$q(electronic bk.)
001451143 020__ $$a3031088816$$q(electronic bk.)
001451143 020__ $$z9783031088803
001451143 020__ $$z3031088808
001451143 0247_ $$a10.1007/978-3-031-08881-0$$2doi
001451143 035__ $$aSP(OCoLC)1350684123
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001451143 08204 $$a572/.3$$223/eng/20221122
001451143 24500 $$aVoltage-gated calcium channels /$$cGerald Werner Zamponi, Norbert Weiss, editors.
001451143 250__ $$a[2022 edition].
001451143 264_1 $$aCham :$$bSpringer,$$c[2022]
001451143 264_4 $$c©2022
001451143 300__ $$a1 online resource (ix, 710 pages) :$$billustrations (chiefly color)
001451143 336__ $$atext$$btxt$$2rdacontent
001451143 337__ $$acomputer$$bc$$2rdamedia
001451143 338__ $$aonline resource$$bcr$$2rdacarrier
001451143 500__ $$aIncludes index.
001451143 500__ $$aOriginally published in 2005.
001451143 5050_ $$aIntro -- Preface -- Contents -- A Lived History of Early Calcium Channel Discoveries Over the Past Half-Century -- Ca2+ as Central Ion for Muscle Contraction -- The "Ca-Spikes" of Crustacean Skeletal Muscles -- "Ca-Spikes" in Heart and Neurons -- How to Look at Ca2+ Currents Through Voltage-Clamp Recordings -- Ca2+ Currents in the Heart and Mollusc Neurons: The Problem of Blocking K+ Currents -- A Convergent View on the Existence of "a" Ca2+ Channel in Excitable Cells -- The "Patch-Clamp" Technique and the Explosive Interest on Ca2+ Channels
001451143 5058_ $$aThe Discovery of the "Low-Voltage Activated" T-Type Channel -- The Unique Properties of T-Type (LVA) Channels -- The Explosive Interest on T-Type Channels -- The Ca2+ Channel Family Growths -- The N-Type Channel -- The P/Q-Type Channel -- The R-Type Channel -- From Ionic Currents to the Molecular Structure of Ca2+ Channels -- The cAMP-Mediated Enhancement of Cardiac L-Type Channels as First Example of Ca2+ Channel Modulation -- Early Observations on the GPCR-Mediated Inhibition of Neuronal Ca2+ Channels -- Towards a Full Understanding of the GPCR-Induced Delayed Activation of HVA Channels
001451143 5058_ $$aLooking Deeper to the Structure and Function of Cav2 Channels Modulation by G proteins -- Take-Home Message -- References -- Part I: Structural and Molecular Aspects of VGCCs -- Subunit Architecture and Atomic Structure of Voltage-Gated Ca2+ Channels -- Introduction -- Purification and Biochemical Characterization of Skeletal Muscle Calcium Channels -- Structures of NaVAb and CaVAb Channels -- Structure of the Skeletal Muscle CaV1.1 Calcium Channel -- Molecular Properties of the CaV2 Family of Calcium Channels -- Structure of CaV2.2 Calcium Channels and Implications for Regulation
001451143 5058_ $$aMolecular Properties and Structure of CaV3 Calcium Channels -- Pharmacology of Calcium Channels -- Conclusion -- References -- Splicing and Editing to Fine-Tune Activity of High Voltage-Activated Calcium Channels -- Generation of mRNA Diversity by A-to-I RNA Editing and Alternative Splicing -- Splice Variations in High Voltage-Activated Calcium Channels -- CaV1.1 Splice Variant in Myotonic Dystrophy -- CaV1.2 Splice Variants in Health and Disease -- Exon 9* in Cardiovascular Diseases -- Mutually Exclusive Exons 1a/1 and Exons 8a/8 -- Exons 21/22 -- Exon 33 and Exon 33L
001451143 506__ $$aAccess limited to authorized users.
001451143 520__ $$aThis book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery. Provides a comprehensive update on the state of knowledge of voltage-gated calcium channels; Examines how calcium channels are pharmacologic targets in the treatment of epilepsy, hypertension, and pain; Explores the new, sophisticated imaging approaches that have increased our ability to measure calcium in live cells; Presents an understanding of the molecular mechanisms that govern calcium channel trafficking and distribution.
001451143 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed November 22, 2022).
001451143 650_0 $$aCalcium channels.
001451143 655_0 $$aElectronic books.
001451143 7001_ $$aZamponi, Gerald W.,$$eeditor.
001451143 7001_ $$aWeiss, Norbert,$$d1978-$$eeditor.
001451143 77608 $$iPrint version: $$z3031088808$$z9783031088803$$w(OCoLC)1319075923
001451143 852__ $$bebk
001451143 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-08881-0$$zOnline Access$$91397441.1
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001451143 980__ $$aBIB
001451143 980__ $$aEBOOK
001451143 982__ $$aEbook
001451143 983__ $$aOnline
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