Linked e-resources
Details
Table of Contents
Intro
Preface
Contents
A Lived History of Early Calcium Channel Discoveries Over the Past Half-Century
Ca2+ as Central Ion for Muscle Contraction
The "Ca-Spikes" of Crustacean Skeletal Muscles
"Ca-Spikes" in Heart and Neurons
How to Look at Ca2+ Currents Through Voltage-Clamp Recordings
Ca2+ Currents in the Heart and Mollusc Neurons: The Problem of Blocking K+ Currents
A Convergent View on the Existence of "a" Ca2+ Channel in Excitable Cells
The "Patch-Clamp" Technique and the Explosive Interest on Ca2+ Channels
The Discovery of the "Low-Voltage Activated" T-Type Channel
The Unique Properties of T-Type (LVA) Channels
The Explosive Interest on T-Type Channels
The Ca2+ Channel Family Growths
The N-Type Channel
The P/Q-Type Channel
The R-Type Channel
From Ionic Currents to the Molecular Structure of Ca2+ Channels
The cAMP-Mediated Enhancement of Cardiac L-Type Channels as First Example of Ca2+ Channel Modulation
Early Observations on the GPCR-Mediated Inhibition of Neuronal Ca2+ Channels
Towards a Full Understanding of the GPCR-Induced Delayed Activation of HVA Channels
Looking Deeper to the Structure and Function of Cav2 Channels Modulation by G proteins
Take-Home Message
References
Part I: Structural and Molecular Aspects of VGCCs
Subunit Architecture and Atomic Structure of Voltage-Gated Ca2+ Channels
Introduction
Purification and Biochemical Characterization of Skeletal Muscle Calcium Channels
Structures of NaVAb and CaVAb Channels
Structure of the Skeletal Muscle CaV1.1 Calcium Channel
Molecular Properties of the CaV2 Family of Calcium Channels
Structure of CaV2.2 Calcium Channels and Implications for Regulation
Molecular Properties and Structure of CaV3 Calcium Channels
Pharmacology of Calcium Channels
Conclusion
References
Splicing and Editing to Fine-Tune Activity of High Voltage-Activated Calcium Channels
Generation of mRNA Diversity by A-to-I RNA Editing and Alternative Splicing
Splice Variations in High Voltage-Activated Calcium Channels
CaV1.1 Splice Variant in Myotonic Dystrophy
CaV1.2 Splice Variants in Health and Disease
Exon 9* in Cardiovascular Diseases
Mutually Exclusive Exons 1a/1 and Exons 8a/8
Exons 21/22
Exon 33 and Exon 33L
Preface
Contents
A Lived History of Early Calcium Channel Discoveries Over the Past Half-Century
Ca2+ as Central Ion for Muscle Contraction
The "Ca-Spikes" of Crustacean Skeletal Muscles
"Ca-Spikes" in Heart and Neurons
How to Look at Ca2+ Currents Through Voltage-Clamp Recordings
Ca2+ Currents in the Heart and Mollusc Neurons: The Problem of Blocking K+ Currents
A Convergent View on the Existence of "a" Ca2+ Channel in Excitable Cells
The "Patch-Clamp" Technique and the Explosive Interest on Ca2+ Channels
The Discovery of the "Low-Voltage Activated" T-Type Channel
The Unique Properties of T-Type (LVA) Channels
The Explosive Interest on T-Type Channels
The Ca2+ Channel Family Growths
The N-Type Channel
The P/Q-Type Channel
The R-Type Channel
From Ionic Currents to the Molecular Structure of Ca2+ Channels
The cAMP-Mediated Enhancement of Cardiac L-Type Channels as First Example of Ca2+ Channel Modulation
Early Observations on the GPCR-Mediated Inhibition of Neuronal Ca2+ Channels
Towards a Full Understanding of the GPCR-Induced Delayed Activation of HVA Channels
Looking Deeper to the Structure and Function of Cav2 Channels Modulation by G proteins
Take-Home Message
References
Part I: Structural and Molecular Aspects of VGCCs
Subunit Architecture and Atomic Structure of Voltage-Gated Ca2+ Channels
Introduction
Purification and Biochemical Characterization of Skeletal Muscle Calcium Channels
Structures of NaVAb and CaVAb Channels
Structure of the Skeletal Muscle CaV1.1 Calcium Channel
Molecular Properties of the CaV2 Family of Calcium Channels
Structure of CaV2.2 Calcium Channels and Implications for Regulation
Molecular Properties and Structure of CaV3 Calcium Channels
Pharmacology of Calcium Channels
Conclusion
References
Splicing and Editing to Fine-Tune Activity of High Voltage-Activated Calcium Channels
Generation of mRNA Diversity by A-to-I RNA Editing and Alternative Splicing
Splice Variations in High Voltage-Activated Calcium Channels
CaV1.1 Splice Variant in Myotonic Dystrophy
CaV1.2 Splice Variants in Health and Disease
Exon 9* in Cardiovascular Diseases
Mutually Exclusive Exons 1a/1 and Exons 8a/8
Exons 21/22
Exon 33 and Exon 33L