Intro
Preface
Contents
Chapter 1: Introduction
1.1 Fluorescence Molecular Tomography
1.2 Mathematic Image Reconstruction
1.2.1 Forward Problem: Fluorescent Photon Diffusion/Transport Model
1.2.2 Inverse Problem
1.3 Fluorescent Probes
Chapter 2: Reconstruction Algorithms
2.1 Linear Reconstruction Algorithm
2.2 Nonlinear Reconstruction Algorithm
2.2.1 Algorithm Implementation
2.2.2 Results
2.2.3 Discussion
Chapter 3: Instrumentation
3.1 Time-Domain FMT System
3.2 Frequency-Domain FMT System
3.3 CW-Domain FMT System

3.4 Contact vs. Noncontact Light Detection Scheme
Chapter 4: Image Enhancing Schemes
4.1 Dual Mesh Scheme
4.2 RTE-Based Fluorescence Molecular Tomography
4.3 The Third-Order Diffusion Equations-Based FMT
4.4 DOT-Guided FMT
4.4.1 Methods and Materials
4.4.2 Results and Discussion
4.5 Fluorophore Lifetime Imaging
4.5.1 Methods and Materials
4.5.2 Results and Discussion
4.6 Full Density FMT
4.6.1 Methods
4.6.2 Results and Discussion
Chapter 5: Bioluminescence Tomography
5.1 BLT Reconstruction Algorithm
5.1.1 Simulations
5.1.2 Experiments

5.1.3 Results and Discussion
5.2 DOT-Guided Bioluminescence Tomography
5.2.1 Methods
5.2.2 Results and Discussion
Chapter 6: Multimodal Approaches
6.1 FMT/PAT
6.1.1 Methods
6.1.2 Results and Discussion
6.1.2.1 Comparison of Image Pattern
6.1.2.2 Comparison of Spatial Resolution
6.1.2.3 Comparison of Sensitivity
6.2 FMT/CT
6.3 FMT/Phase-Contrast CT
6.4 FMT/MRI
6.5 FMT/CT/SPECT
Chapter 7: Miniaturized Fluorescence Molecular Tomography
7.1 Handheld FMT
7.1.1 Methods
7.1.2 Results and Discussion
7.1.2.1 Simulations

7.1.2.2 Phantom Experiments
7.1.2.3 Mouse Experiments
7.2 FMT Pen
7.2.1 Methods
7.2.2 Results and Discussion
7.2.2.1 Phantom Experiments
7.2.2.2 Animal Experiments
7.3 Endoscopic FMT
7.3.1 Methods
7.3.2 Results and Discussion
Chapter 8: Animal Studies and Clinical Applications
8.1 Fruit Flies
8.1.1 Pupa with Dye-Containing Microtube
8.1.2 In Vivo Pupa with DsRed Reporter
8.2 Tumor Imaging in Animals
8.2.1 Ovarian Tumor
8.2.1.1 Methods
Cell Lines and HER-2/Neu-Specific Affibody Conjugation to Magnetic Iron Oxide Nanoparticles (IONPs)

Orthotopic Human Ovarian Cancer Xenograft Model
Fluorescence Molecular Tomography Imaging System
Photoacoustic Tomography System
In Vivo Imaging in Animal Tumor Models
Histology Analysis
8.2.1.2 Results and Discussion
8.2.2 Lung Tumor
8.2.2.1 Methods
8.2.2.2 Results and Discussion
8.2.3 Brain Tumor
8.2.3.1 Methods
8.2.3.2 Results and Discussion
8.3 Breast Tumor Imaging in Humans
8.3.1 Methods
8.3.2 Results and Discussion
8.4 Tumor Response to Therapies
8.4.1 Methods
8.4.2 Results and Discussion
8.5 Quantification of Receptor Density