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001453121 001__ 1453121
001453121 003__ OCoLC
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001453121 019__ $$a1348485825
001453121 020__ $$a9783031123900$$q(electronic bk.)
001453121 020__ $$a3031123905$$q(electronic bk.)
001453121 020__ $$z9783031123894
001453121 020__ $$z3031123891
001453121 0247_ $$a10.1007/978-3-031-12390-0$$2doi
001453121 035__ $$aSP(OCoLC)1348380190
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001453121 049__ $$aISEA
001453121 050_4 $$aQP702.G577
001453121 08204 $$a572/.567$$223/eng/20221031
001453121 24500 $$aGlycobiology of the nervous system /$$cRobert K. Yu, Cara-Lynne Schengrund, editors.
001453121 250__ $$aSecond edition.
001453121 264_1 $$aCham :$$bSpringer,$$c[2023]
001453121 264_4 $$c©2023
001453121 300__ $$a1 online resource (xii, 501 pages) :$$billustrations (some color).
001453121 336__ $$atext$$btxt$$2rdacontent
001453121 337__ $$acomputer$$bc$$2rdamedia
001453121 338__ $$aonline resource$$bcr$$2rdacarrier
001453121 4901_ $$aAdvances in neurobiology ;$$vvolume 29
001453121 500__ $$aPrevious edition: 2014.
001453121 504__ $$aIncludes bibliographical references and index.
001453121 5050_ $$aIntro -- Preface -- Postscript: In Memoriam -- Contents -- Chapter 1: Introduction to the Complexity of Cell Surface and Tissue Matrix Glycoconjugates -- 1 Introduction -- 2 Monosaccharides: Building Blocks of Glycans -- 3 Formation of Oligosaccharides -- 4 Classification of Glycans -- 5 Structural Features of N-Glycans -- 6 Structural Features of O-Glycans -- 7 Biosynthesis of N- and O-Glycans -- 8 Glycosphingolipids -- 9 Structural Features of the Glycan Moieties of Glycosphingolipids -- 10 Synthesis and Functions of the Glycan Moieties of Glycolipids
001453121 5058_ $$a11 Glycosylphosphatidylinositol Anchors: A Special Group of Glycolipids -- 12 Glycosaminoglycans and Proteoglycans -- 13 Glycan-Protein Interactions -- 14 Glycans of Cell Surface Glycoconjugates Perform a Variety of Functions -- 15 Summary -- References -- Chapter 2: Cells of the Central Nervous System: An Overview of Their Structure and Function -- 1 Introduction -- 2 Neurons -- 2.1 Neuronal Cell Body -- 2.2 Cytoskeleton -- 2.3 Dendrites -- 2.4 Axon -- 2.5 Synapse -- 3 Supporting Cells -- 3.1 Astrocytes -- 3.2 Oligodendrocytes -- 3.3 Microglia -- 3.4 NG2 Cells (Polydendrocytes)
001453121 5058_ $$a3.5 Ependymal Cells -- 4 Extracellular Matrix -- 5 Concluding Remarks -- References -- Chapter 3: Synthesis, Processing, and Function of N-Glycans in N-Glycoproteins -- 1 Introduction -- 2 N-glycans Are First Born on a Lipid and Then Transferred "En Bloc" onto the Nascent N-glycoprotein in the ER -- 3 Trimming, Reglycosylation, and Remodeling: There Are Many Ways of N-glycoprotein Processing in the ER and Golgi -- 4 The Essential Toolbox of a Glycobiologist: A Brief History of the Discovery of N-glycoprotein Biosynthesis Inhibitors and Their Impact on Our Understanding of N-glycan Processing
001453121 5058_ $$a5 Sweetening the Bond or Sugar-Coating Bad News: Recent Advances in the Role of N-glycans for Virus Infections and Immune Responses -- 6 Sweet Encounters of Glycoproteins and Glycolipids: N-glycans Affect the Subcellular Distribution and Complex Formation of Enzymes in Glycolipid Biosynthesis -- 7 Conclusions and Epilogue: The Tale of the Tail That Wags the Dog -- References -- Chapter 4: Synthesis of O-Linked Glycoconjugates in the Nervous System -- 1 Introduction -- 2 Biosynthesis of O-Linked Proteins -- 2.1 O-GalNAcylation -- 2.2 O-Mannosylation -- 2.3 O-GlcNAcylation -- 2.4 O-Xylosylation
001453121 5058_ $$a2.5 O-Fucosylation -- 2.6 O-Glucosylation -- 3 Biosynthesis of O-Linked Lipids -- 3.1 Glucosylceramide and Glycosphingolipids -- 3.2 Galactosylceramide and Glycosphingolipids -- 3.3 GlcCer and GM3 Synthase Deficiency in Human and Mouse -- 3.4 Other O-Linked Lipids - New Glucose-Related Lipids -- 4 Conclusions -- References -- Chapter 5: Chemistry and Function of Glycosaminoglycans in the Nervous System -- 1 Introduction -- 2 Glycosaminoglycan Structure and Chemistry -- 2.1 Chondroitin Sulfate (CS) -- 2.1.1 Structure and Chemistry -- 2.1.2 Synthesis and Modification of CS Chains
001453121 506__ $$aAccess limited to authorized users.
001453121 520__ $$aThis new edition provides comprehensive coverage of the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system. Basic fundamental principles as well as the latest developments in neural glycobiology are discussed. Topics covered range from the structure and metabolism of the saccharide chains and current approaches used in their study, to changes glycoconjugates undergo during development and aging of the nervous system and the roles they have in neurological disease. New topics include a detailed discussion of cells found within the nervous system, an extensive listing of congenital disorders of glycosylation of both proteins and lipids, the roles of glycans in neuronal axon growth/guidance and voltage-gated channels, the role of intra-lysosomal luminal vesicles in lysosomal storage disorders, and, in the time of the COVID-19 pandemic, the role of carbohydrates in infection by SARS-CoV-2. The breadth and depth of topics covered make this an essential reference for those new to the field as well as for more experienced investigators.
001453121 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed October 31, 2022).
001453121 650_0 $$aGlycomics.
001453121 650_0 $$aNervous system$$xMicrobiology.
001453121 650_0 $$aGlycoconjugates.
001453121 650_0 $$aNeurobiology.
001453121 655_0 $$aElectronic books.
001453121 7001_ $$aYu, Robert K.,$$eeditor.$$1https://isni.org/isni/0000000445405001
001453121 7001_ $$aSchengrund, Cara-Lynne,$$eeditor.$$1https://isni.org/isni/0000000113555038
001453121 77608 $$iPrint version:$$tGlycobiology of the nervous system.$$bSecond edition.$$dCham : Springer, 2022$$z9783031123894$$w(OCoLC)1346320314
001453121 830_0 $$aAdvances in neurobiology ;$$v29.
001453121 852__ $$bebk
001453121 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-12390-0$$zOnline Access$$91397441.1
001453121 909CO $$ooai:library.usi.edu:1453121$$pGLOBAL_SET
001453121 980__ $$aBIB
001453121 980__ $$aEBOOK
001453121 982__ $$aEbook
001453121 983__ $$aOnline
001453121 994__ $$a92$$bISE