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Table of Contents
Intro
Supervisor's Foreword
Abstract
Introduction
Synthesis of Nitro-Containing Compounds Through Multistep Continuous Flow
Anion Exchange Resins as Catalysts for Direct Aldol-Type Reactions
Polysilane-Supported Pd Catalysts for Continuous-Flow Hydrogenations
Aldol-Type Reactions and Hydrogenations-Mediated Continuous-Flow Synthesis of APIs
Conclusion
Acknowledgement
Contents
Abbreviations
1 Introduction and Strategy
1.1 Continuous-Flow Synthesis
1.2 Four Types of Flow Reactions
1.3 Continuous-Flow Reactions Using Heterogeneous Catalysts (Type IV)
1.4 Multistep Continuous-Flow Synthesis of Fine Chemicals
1.5 Aldol-Hydrogenation Strategy
References
2 Synthesis of Nitro-Containing Compounds Through Multistep Continuous Flow with Heterogeneous Catalysts
2.1 Background
2.2 Nitroalkene Synthesis from Nitromethane and Aldehydes
2.3 Metal Oxide-Catalyzed Conjugate Additions to Nitroalkenes
2.4 Solid Acid-Catalyzed Nucleophilic Addition of Indole
2.5 Silica Immobilized DMAP Catalyzed Morita-Baylis-Hillman Reaction
2.6 Polystyrene Immobilized Peptide Catalyzed Conjugate Addition of Aldehyde
2.7 Silica Immobilized Secondary Amine Catalyzed Intermolecular Cyclization with Dithiane
2.8 Three-Step Transformation of Nitrocompounds
2.9 Conclusion
References
3 Polysilane-Supported Pd Catalysts for Continuous-Flow Hydrogenations
3.1 Background
3.2 Preparation of Polysilane-Supported Pd/SiO2 Catalysts
3.3 Hydrogenation of Decane Nitrile Using DMPSi-Pd/SiO2 Under Continuous-Flow Conditions
3.4 Substrate Scope for Aliphatic and Benzyl Nitriles
3.5 Optimization for Aromatic Nitriles
3.6 Substrate Scope for Aromatic Nitriles
3.7 Lifetime and Reaching Experiments
3.8 Control Experiments
3.9 Optimization for Hydrogenation Nitrocompounds
3.10 Substrate Scope for Hydrogenation Nitrocompounds
3.11 Modification of Catalyst Preparation
3.12 Hydrogenation of Ketimine
3.13 Hydrogenation of Ketimine Under Continuous Flow Conditions
3.14 Substrate Generality of PhMePSi-[Pd/SiO2]
3.15 Summary
References
4 Anion Exchange Resins as Catalysts for Direct Aldol-Type Reactions of Ketones, Esters, and Nitriles Under Continuous-Flow Conditions
4.1 Background
4.2 Aldol-Type Reactions with Ketone Under Batch Conditions
Supervisor's Foreword
Abstract
Introduction
Synthesis of Nitro-Containing Compounds Through Multistep Continuous Flow
Anion Exchange Resins as Catalysts for Direct Aldol-Type Reactions
Polysilane-Supported Pd Catalysts for Continuous-Flow Hydrogenations
Aldol-Type Reactions and Hydrogenations-Mediated Continuous-Flow Synthesis of APIs
Conclusion
Acknowledgement
Contents
Abbreviations
1 Introduction and Strategy
1.1 Continuous-Flow Synthesis
1.2 Four Types of Flow Reactions
1.3 Continuous-Flow Reactions Using Heterogeneous Catalysts (Type IV)
1.4 Multistep Continuous-Flow Synthesis of Fine Chemicals
1.5 Aldol-Hydrogenation Strategy
References
2 Synthesis of Nitro-Containing Compounds Through Multistep Continuous Flow with Heterogeneous Catalysts
2.1 Background
2.2 Nitroalkene Synthesis from Nitromethane and Aldehydes
2.3 Metal Oxide-Catalyzed Conjugate Additions to Nitroalkenes
2.4 Solid Acid-Catalyzed Nucleophilic Addition of Indole
2.5 Silica Immobilized DMAP Catalyzed Morita-Baylis-Hillman Reaction
2.6 Polystyrene Immobilized Peptide Catalyzed Conjugate Addition of Aldehyde
2.7 Silica Immobilized Secondary Amine Catalyzed Intermolecular Cyclization with Dithiane
2.8 Three-Step Transformation of Nitrocompounds
2.9 Conclusion
References
3 Polysilane-Supported Pd Catalysts for Continuous-Flow Hydrogenations
3.1 Background
3.2 Preparation of Polysilane-Supported Pd/SiO2 Catalysts
3.3 Hydrogenation of Decane Nitrile Using DMPSi-Pd/SiO2 Under Continuous-Flow Conditions
3.4 Substrate Scope for Aliphatic and Benzyl Nitriles
3.5 Optimization for Aromatic Nitriles
3.6 Substrate Scope for Aromatic Nitriles
3.7 Lifetime and Reaching Experiments
3.8 Control Experiments
3.9 Optimization for Hydrogenation Nitrocompounds
3.10 Substrate Scope for Hydrogenation Nitrocompounds
3.11 Modification of Catalyst Preparation
3.12 Hydrogenation of Ketimine
3.13 Hydrogenation of Ketimine Under Continuous Flow Conditions
3.14 Substrate Generality of PhMePSi-[Pd/SiO2]
3.15 Summary
References
4 Anion Exchange Resins as Catalysts for Direct Aldol-Type Reactions of Ketones, Esters, and Nitriles Under Continuous-Flow Conditions
4.1 Background
4.2 Aldol-Type Reactions with Ketone Under Batch Conditions