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001453602 001__ 1453602
001453602 003__ OCoLC
001453602 005__ 20230314003435.0
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001453602 019__ $$a1356008753$$a1357116817
001453602 020__ $$a9783031218200$$q(electronic bk.)
001453602 020__ $$a3031218205$$q(electronic bk.)
001453602 020__ $$z3031218191
001453602 020__ $$z9783031218194
001453602 0247_ $$a10.1007/978-3-031-21820-0$$2doi
001453602 035__ $$aSP(OCoLC)1355267788
001453602 040__ $$aYDX$$beng$$cYDX$$dGW5XE$$dSTF$$dEBLCP$$dN$T$$dUKAHL
001453602 049__ $$aISEA
001453602 050_4 $$aQH442
001453602 08204 $$a660.6/5$$223/eng/20230110
001453602 1001_ $$aParis, Katherine.
001453602 24510 $$aGenome editing and biological weapons:$$bassessing the risk of misuse /$$cKatherine Paris.
001453602 260__ $$aCham, Switzerland :$$bSpringer,$$c2023.
001453602 300__ $$a1 online resource
001453602 504__ $$aIncludes bibliographical references.
001453602 5050_ $$aChapter 1: Introduction: Rapid Technological Advancements amid Rising Concerns of Misuse -- Chapter 2: Background: Genome Editing with Programmable Nucleases -- Chapter 3: Applying Genetic Engineering to Biological Weapons -- Chapter 4: Risk of Misuse Assessment: Part I -- Chapter 5: Risk of Misuse Assessment: Part II -- Chapter 6: Raising the Alarm on CRISPR -- Chapter 7: Conclusion: Reducing the Perils from the Misuse of Genome Editing.
001453602 506__ $$aAccess limited to authorized users.
001453602 520__ $$aThis monograph introduces current genome editing technologiesclustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated (Cas) systems, transcription activator-like effector nucleases (TALENs), and zinc-finger nucleases (ZFNs)and provides an assessment of the risk of misuse of these technologies based on the following parameters: accessibility, ease of misuse, magnitude of potential harm, and imminence of potential misuse. The findings from this assessment are applied to analyze and evaluate the threat posed by the intentional misuse of genome editing technologies to develop biological weapons. Furthermore, the book discusses the implications of misuse for different applications of genome editing, such as making existing pathogens more dangerous, modifying the human microbiome, weaponizing gene drives, engineering super soldiers, and augmenting the general population to confer economic advantages. Technologies that enable genome editing with programmable nucleasesincluding CRISPR, TALEN, and ZFNallow for the precise genetic modification of organisms and cultured cells. While these technologies are used for a variety of beneficial applications, intelligence and defense experts have raised concerns that genome editing technologies, especially CRISPR, could be misused to develop new and improved biological weapons. Furthermore, experts worry that the number and type of actors who could potentially misuse genome editing is dramatically increasing given the democratization of biology, which is allowing biology to become more accessible to everyone including nonexperts. The book provides a comprehensive assessment of how feasible it is for users with different levels of knowledge and skill to acquire and then to apply the technologies to develop a biological weapon. It also provides an assessment of governability and a tailored set of recommendations that address security concerns. These recommendations are sensitive to the cost-benefit trade-off of regulating genome editing technologies. The book targets researchers as well as intelligence analysts, defense and security personnel, and policymakers.
001453602 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed January 10, 2023).
001453602 650_0 $$aGene editing.
001453602 650_0 $$aCRISPR (Genetics)
001453602 650_0 $$aBiological weapons.
001453602 655_0 $$aElectronic books.
001453602 77608 $$iPrint version:$$z3031218191$$z9783031218194$$w(OCoLC)1348477682
001453602 852__ $$bebk
001453602 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-21820-0$$zOnline Access$$91397441.1
001453602 909CO $$ooai:library.usi.edu:1453602$$pGLOBAL_SET
001453602 980__ $$aBIB
001453602 980__ $$aEBOOK
001453602 982__ $$aEbook
001453602 983__ $$aOnline
001453602 994__ $$a92$$bISE