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001453744 019__ $$a1357017205$$a1358458144
001453744 020__ $$a9783031214103$$q(electronic bk.)
001453744 020__ $$a3031214102$$q(electronic bk.)
001453744 020__ $$z9783031214097
001453744 020__ $$z3031214099
001453744 0247_ $$a10.1007/978-3-031-21410-3$$2doi
001453744 035__ $$aSP(OCoLC)1356943862
001453744 040__ $$aYDX$$beng$$erda$$epn$$cYDX$$dGW5XE$$dEBLCP$$dOCLCQ$$dUKAHL
001453744 049__ $$aISEA
001453744 050_4 $$aQP86
001453744 08204 $$a612.6/7$$223/eng/20230112
001453744 24500 $$aBiochemistry and cell biology of ageing.$$nPart III,$$pBiomedical science /$$cJ. Robin Harris, Viktor I. Korolchuk, editors.
001453744 24630 $$aBiomedical science
001453744 264_1 $$aCham :$$bSpringer,$$c[2023]
001453744 264_4 $$c©2023
001453744 300__ $$a1 online resource (ix, 424 pages) :$$billustrations.
001453744 336__ $$atext$$btxt$$2rdacontent
001453744 337__ $$acomputer$$bc$$2rdamedia
001453744 338__ $$aonline resource$$bcr$$2rdacarrier
001453744 4901_ $$aSubcellular biochemistry ;$$vvolume 102
001453744 5050_ $$aIntro -- Preface -- Contents -- About the Editors -- Chapter 1: Introduction: Progression of the Science of Ageing -- Introduction -- References -- Chapter 2: Chromatin Structure from Development to Ageing -- Introduction -- Nuclear Architecture -- The Nuclear Envelope -- Nuclear Lamina -- Chromosome Territories -- Chromatin 3D Organization and Dynamics -- Compartments -- Topologically Associated Domains (TADs) -- Lamina-Associated Domains (LADs) -- Chromatin Restructuring During Development -- DNA Methylation -- Histone Variants -- Histone Modifications -- Nuclear Remodeling in Development
001453744 5058_ $$aLamins Regulate Nuclear Structure and Chromatin Organization During Development -- Programmed Cellular Senescence -- Chromatin Remodeling in Ageing -- Persistent Cellular Senescence -- Changes in Chromatin Structure and Histone Variants in Cellular Senescence -- DNA Methylation -- Histone Variants and Modifications -- Nuclear and 3D Genome Remodeling in Ageing -- The Role of Lamins in Regulating Chromatin Organization During Ageing -- Concluding Remarks -- References -- Chapter 3: The Nuclear Envelope in Ageing and Progeria -- Introduction
001453744 5058_ $$aThe Nuclear Lamina in Ageing and Premature Ageing Syndromes -- Nuclear Pore Complex Turnover and Decline in Ageing -- The Implication of Nucleocytoplasmic Transport in Neurodegenerative Disease -- RNA-Binding Proteins and Neurodegenerative Diseases -- Peptide Repeat Toxicity and NPC Function -- Additional Implications of NCT in Neurodegenerative Diseases -- Concluding Remarks -- References -- Chapter 4: Mitochondrial DNA Mutations and Ageing -- Introduction -- Mitochondrial Structure and Function -- Oxidative Phosphorylation -- Mitochondrial Genetics -- Mitochondrial DNA Mutations in Ageing
001453744 5058_ $$aMtDNA Deletions -- MtDNA Point Mutations -- Mouse Models of Mitochondrial Alterations with Ageing -- Mitochondrial Function and Stem Cell Ageing -- MtDNA Mutations and Stem Cell Ageing -- Mitochondrial Regulation of the Ageing Immune System -- Targeting Mitochondria in Ageing -- Concluding Remarks -- References -- 5: The Proteasome and Ageing -- Introduction -- The Proteasome: A Brief Overview -- Cellular Senescence and the Proteasome -- Muscle Ageing and the Proteasome -- Skin Ageing and the Proteasome -- Brain Ageing and the Proteasome -- Proteasome and Age-Related Neurodegenerative Diseases
001453744 5058_ $$aProteasome and Longevity -- Other Components of the Ubiquitin-Proteasome Pathway Implicated in Ageing -- Activating the Proteasome to Decelerate the Ageing Process -- Conclusion and Future Directions -- References -- 6: Gap Junctions and Ageing -- Introduction -- Gap Junctions and the Connexin Family -- Regulation of Gap Junctions at the Molecular Level -- Gene Structure and Transcription -- Translation -- Trafficking -- Posttranslational Modification of Connexins -- Heart -- Brain -- The Ocular System -- Bone -- Other Tissues -- Concluding Remarks -- References
001453744 506__ $$aAccess limited to authorized users.
001453744 520__ $$aThis, our third book on the Biochemistry and Cell Biology of Ageing in the Subcellular Biochemistry series, expands on the content of Part I, by covering additional biomedical topics. The 16 chapters included here, contributed by international knowledgeable scientists, review these further interesting topics at an advanced level. Following an Introductory chapter, these topics are included: Chromatin Structure from Development to Ageing, the Nuclear Envelope in Ageing and Progeria, Mitochondrial DNA Mutations and Ageing, the Proteasome and Ageing, Gap Junctions and Ageing, Cellular Senescence and Ageing, Therapeutic Opportunities Presented by Modulation of Cellular Senescence, Ageing at Molecular Level: Role of MicroRNAs, CircRNA and Ageing, Extracellular Vesicles and Cellular Ageing,Fibrinogen, Coagulation and Ageing, An Insight into Platelets at Older Age: Cellular and Clinical Perspectives, Ageing Skeletal Muscle: The Ubiquitous Muscle Stem Cell, Age-related Changes in Central Nervous System 5-Hydroxytryptamine Signalling and its Potential effects on the Regulation of Lifespan, and Systems Biology of Ageing. The book is primarily directed to advanced biomedical science and medical students, postgraduates, researchers and academics in the field of Ageing. A further companion volume of the series (Part IV) covering the more Clinical Science aspects will be published soon. The seemingly endless expansion of ageing research continues to throw up important areas, that may well be covered in future volumes, together with updates of rapidly moving subjects. Thus, a further book on Anti-ageing Interventions (Part V) is under production.
001453744 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed January 12, 2023).
001453744 650_0 $$aAging$$xMolecular aspects.
001453744 650_0 $$aCells$$xAging.
001453744 650_0 $$aClinical biochemistry.
001453744 655_0 $$aElectronic books.
001453744 7001_ $$aHarris, J. Robin$$q(James Robin),$$eeditor.
001453744 7001_ $$aKorolchuk, Viktor I.,$$eeditor.
001453744 77608 $$iPrint version: $$z3031214099$$z9783031214097$$w(OCoLC)1347782530
001453744 830_0 $$aSub-cellular biochemistry ;$$vv. 102.
001453744 852__ $$bebk
001453744 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-21410-3$$zOnline Access$$91397441.1
001453744 909CO $$ooai:library.usi.edu:1453744$$pGLOBAL_SET
001453744 980__ $$aBIB
001453744 980__ $$aEBOOK
001453744 982__ $$aEbook
001453744 983__ $$aOnline
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