Intro
Preface
Contents
Introduction to ``The Mesentery in Inflammation ́́
1 Introduction: Inflammation and the Mesentery
2 Overview of Chapters
3 The Mesentery
4 Inflammation of the Mesentery
5 The Mesenteric Interstitium
6 The Mesenteric Lymphatic Framework
7 General Immunology of the Mesentery
8 Bacterial Translocation
9 The Effects of Mesenteric Inflammation on Adjoining Intestine
10 Targeting the Mesentery
11 Conclusion
References
The Development and Anatomy of the Mesentery
1 Introduction
2 The Mesentery Redefined

3 The Mesenteric Model of Abdominal Anatomy
4 Histology of the Mesentery
5 Vasculature of the Mesentery
6 The Mesentery and the Immune System
7 Implications for Our Understanding of Abdominal Inflammation
8 Implications for Treatment
9 Implications for Medical Practice in General
10 Conclusion
References
The Interstitium of the Mesentery: Contents and Inter-organ Connections
1 Introduction
2 Categories of Interstitial Spaces
3 Interstitial Spaces of the Mesentery
3.1 Continuity of Interstitial Spaces Within the Mesentery

3.2 Continuity Between the Mesenteric Interstitium and Extra-Mesenteric Tissues
4 Resident Cells of the Interstitium
4.1 Interstitial Lining Cells and Other Stromal Cells
4.2 Macrophages
4.3 Mast Cells
4.4 Cell Derived Exosomes
5 The Matrix of the Interstitium
5.1 Extracellular Matrix
5.2 Fluid Contents of the Interstitium
6 The Mesenteric Interstitium in Disease
7 Conclusion
References
Mesenteric Organ Lymphatics in Abdominal Inflammation
1 Introduction
2 Anatomy of the Mesenteric Lymphatic Vasculature
3 Developmental Origins of Mesenteric LECs

4 Mesenteric Lymphatic Molecular Regulation
5 Function of Mesenteric Lymphatics
6 Mesenteric Lymphatics and Abdominal Inflammation
6.1 Obesity
6.2 Inflammatory Bowel Disease
6.3 Intestinal Infection
7 Translational Perspectives
References
The Immunological Importance of the Mesentery
1 Phenotypic Findings and Functional Implications
1.1 Adipocyte Hyperplasia: Immune Nutrition?
1.2 Only Adipocyte Hyperplasia?
2 Adipokines
2.1 Leptin
2.2 Adiponectin
3 Adipocytes as Cells of the Innate Immune System
4 Immune Cell Infiltration and Function

4.1 Macrophages
4.2 T and B Cells
4.3 Intestinal Barrier
5 Working Model
6 Conclusion
References
Bacterial Translocation to the Mesentery
1 Concept of Bacterial Translocation and Methods of Detection
1.1 Historical Context
1.2 Detection Methods
2 Translocation of the Gut Microbiome in Chronic Inflammation
2.1 The Leaky Gut Hypothesis
2.2 Bacterial Translocation Patterns in Distinct Chronic Inflammatory Diseases
2.3 Microbial Influence on Mesenteric Adipose Immune and Metabolic Function
2.4 Bacterial Translocation and Creeping Fat