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001453779 001__ 1453779
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001453779 019__ $$a1356798083$$a1356798206
001453779 020__ $$a3031147324$$qelectronic book
001453779 020__ $$a9783031147326$$q(electronic bk.)
001453779 020__ $$z9783031147319
001453779 020__ $$z3031147316
001453779 0247_ $$a10.1007/978-3-031-14732-6$$2doi
001453779 035__ $$aSP(OCoLC)1357149602
001453779 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dYDX$$dN$T$$dUKAHL
001453779 049__ $$aISEA
001453779 050_4 $$aRC280.B7$$bH86 2022
001453779 08204 $$a616.99/481$$223/eng/20230109
001453779 24500 $$aHuman brain and spinal cord tumors :$$bfrom bench to bedside.$$nVolume 1,$$pNeuroimmunology and neurogenetics /$$cNima Rezaei, Sara Hanaei, editors.
001453779 24630 $$aVolume 1,$$pNeuroimmunology and neurogenetics
001453779 24630 $$aNeuroimmunology and neurogenetics
001453779 264_1 $$aCham :$$bSpringer,$$c2022.
001453779 300__ $$a1 online resource (1 volume) :$$billustrations (black and white, and colour)
001453779 336__ $$atext$$btxt$$2rdacontent
001453779 337__ $$acomputer$$bc$$2rdamedia
001453779 338__ $$aonline resource$$bcr$$2rdacarrier
001453779 4901_ $$aAdvances in experimental medicine and biology ;$$vvolume 1394
001453779 504__ $$aIncludes bibliographical references.
001453779 5050_ $$aChaptre 1. Brain and Spinal Cord Tumors Among the Life-Threatening Health Problems: An Introduction -- Chaptre 2. Epidemiology of Brain and Spinal Cord Tumors -- Chaptre 3. The Role of Neuro-inflammation and Innate Immunity in Pathophysiology of Brain and Spinal Cord Tumors -- Chaptre 4. The Role of Cellular Immunity and Adaptive Immunity in Pathophysiology of Brain and Spinal Cord Tumors -- Chaptre 5. Immunotherapy as a New Therapeutic Approach for Brain and Spinal Cord Tumors -- Chaptre 6. Cell of Origin of Brain and Spinal Cord Tumors -- Chaptre 7. The Role of Bioinformatics and Imaging Models in Tumorigenesis and Treatment Response of Brain and Spinal Cord Neoplasms -- Chaptre 8. The Role of Epigenetics in Brain and Spinal Cord Tumors -- Chaptre 9. Stem Cells and Targeted Gene Therapy in Brain and Spinal Cord Tumors -- Chaptre 10. Nutrition and Diet: A Double-Edged Sword in Development and Treatment of Brain Tumors -- Chaptre 11. The Role of Nanotechnology in Brain Tumors -- Chaptre 12. The Role of Nanotechnology in Spinal Cord Tumors -- Chaptre 13. The Economic Burden of Malignant Brain Tumors.
001453779 506__ $$aAccess limited to authorized users.
001453779 520__ $$aBrain tumors comprise about 59% of all human neoplasms; and interestingly the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. Besides to the morphologic and histopathologic characteristics, and as each pathologic states first starts with molecular alterations, each tumor may have its own story in the matter of activating tumorigenesis pathways and having specific molecular characteristics. Importantly, the molecular classification of tumors has been highly considered in the past few decades for taking the most appropriate therapeutic approach. On the other hand, the tumors shall have tumor-scape mechanisms preventing the immunologic system to eliminate its invasion. The failure of innate and acquired immune system to defeat tumorigenesis mechanisms would consequently result in tumor development. Interestingly, the neuro-immunologic mechanism plays a role in development of psychiatric manifestations of brain tumors as well. Taking all these to account, the different arms of innate immunity, acquired immunity, and genetics have been approached to defeat development and/or progression of such tumors. Accordingly, the activation immunotherapeutic approaches focus on activating or strengthening the anti-tumor immunologic pathways in order to assist the weakened immune system to defeat the tumor (such as Dendritic cell vaccination, DNA vaccines, peptide vaccines, viral vector-based vaccines, monoclonal antibodies, and CAR T-cell therapy). In addition to immunologic components of brain and spinal cord tumors, numerous genes and genetic pathways have been recognized to take part in tumorigenesis. Taking these non-immune genetic pathways to account, some other therapeutic approaches such as stem cell therapy and gene therapy have been developed in the new era of cancer treatment. Moreover, and besides the biologic and medical aspects of these tumors, different physical/mathematical models have been proposed to either explain or predict tumor behavior. Such models would be advantageous in developing new therapeutic modalities in pre-clinical stages and enter new eras in cancer treatment. The first book of Human Brain and Spinal Cord Tumors, Neuro-immunology and Neuro-genetics, will mainly discuss the neuro-immunology and neurogenetic pathways associated with development of brain and spinal cord tumor. After a short introduction chapter, this book will focus on the role of innate and acquired immunity on development of these tumors and then the immunotherapeutic approaches to defeat these tumorigenesis mechanisms. This book will then focus on genetic aspects of brain and spinal cord tumors and bioinformatics models to describe the behavioral patterns of these tumors, as well as associated therapeutic approaches such as stem cell therapy and gene therapy. This volume of book could be useful for experts in basic sciences, mainly geneticists and immunologists, and also physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists and neuroradiologists.
001453779 650_0 $$aBrain$$xTumors$$xImmunotherapy.
001453779 650_0 $$aSpinal cord$$xTumors$$xImmunotherapy.
001453779 650_0 $$aNeuroimmunology.
001453779 650_0 $$aNeurogenetics.
001453779 655_0 $$aElectronic books.
001453779 7001_ $$aRezaei, Nima,$$eeditor.$$1https://isni.org/isni/0000000055228652
001453779 7001_ $$aHanaei, Sara,$$eeditor.
001453779 77608 $$iPrint version:$$tHuman brain and spinal cord tumors : Volume 1, Neuroimmunology and neurogenetics.$$dCham : Springer, 2022$$z9783031147319$$w(OCoLC)1346945179
001453779 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 1394.
001453779 852__ $$bebk
001453779 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-14732-6$$zOnline Access$$91397441.1
001453779 909CO $$ooai:library.usi.edu:1453779$$pGLOBAL_SET
001453779 980__ $$aBIB
001453779 980__ $$aEBOOK
001453779 982__ $$aEbook
001453779 983__ $$aOnline
001453779 994__ $$a92$$bISE