001454041 000__ 04002cam\a2200529\i\4500
001454041 001__ 1454041
001454041 003__ OCoLC
001454041 005__ 20230314003458.0
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001454041 007__ cr\un\nnnunnun
001454041 008__ 230119s2023\\\\sz\a\\\\ob\\\\000\0\eng\d
001454041 019__ $$a1356797435$$a1357015632
001454041 020__ $$a9783031200250$$q(electronic bk.)
001454041 020__ $$a303120025X$$q(electronic bk.)
001454041 020__ $$z9783031200243$$q(print)
001454041 020__ $$z3031200241
001454041 0247_ $$a10.1007/978-3-031-20025-0$$2doi
001454041 035__ $$aSP(OCoLC)1362528079
001454041 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dYDX$$dEBLCP$$dOCLCQ$$dUKAHL
001454041 049__ $$aISEA
001454041 050_4 $$aRM301.5
001454041 08204 $$a615.7$$223/eng/20230119
001454041 1001_ $$aMacheras, P.$$q(Panos),$$eauthor.
001454041 24510 $$aRevising oral pharmacokinetics, bioavailability and bioequivalence based on the finite absorption time concept /$$cPanos Macheras, Athanasios A. Tsekouras.
001454041 264_1 $$aCham :$$bSpringer,$$c2023.
001454041 300__ $$a1 online resource (xv, 129 pages) :$$billustrations
001454041 336__ $$atext$$btxt$$2rdacontent
001454041 337__ $$acomputer$$bc$$2rdamedia
001454041 338__ $$aonline resource$$bcr$$2rdacarrier
001454041 504__ $$aIncludes bibliographical references.
001454041 5050_ $$aPart I: Oral Pharmacokinetics -- Chapter 1. From Bateman (1908) To Dost (1953) -- Chapter 2. The Unphysical Hypothesis Of Infinite Absorption Time -- Chapter 3. The Finite Absorption Time (Fat) Concept -- Chapter 4. The Rise Of Physiologically Based Finite Time Pharmacokinetic (Pbftpk) Models -- Part II: Bioavailability-Bioequivalence -- Chapter 5. History Of The Bioavailability-Bioequivalence Concepts -- Chapter 6. Therapeutic Equivalence Based On Bioequivalence Studies -- Chapter 7. Bioavailability Under The Prism Of Finite Absorption Time -- Chapter 8. Bioequivalence Under The Prism Of Finite Absorption Time.
001454041 506__ $$aAccess limited to authorized users.
001454041 520__ $$aThis book casts new light on the field of oral drug absorption. It outlines both the concept of the past and the novel concept of Finite Absorption Time (FAT). In addition, the authors explore the correlated need for re-definition of bioavailability, bioequivalence providing a plethora of experimental data. Accordingly, this book is intended for academics/students or scientists working in pharmaceutical industries, regulatory agencies, and contract research organizations. It can be used for teaching purposes in under- and post-graduate courses dealing with biopharmaceutics, pharmacokinetics and biomedical engineering. This excellent text serves as a historical review of drug absorption kinetics and its application to bioavailability and bioequivalence. However, its main thrust is the application of the authors' innovative new approaches to modifying these processes utilizing concepts of finite absorption time (FAT) and physiologically based finite time pharmacokinetic (PBFTPK) models. The work described in detail is based on the innovative experimental studies, many in depth examples and simulations, and the authors' outstanding theoretical contributions to our understanding of drug gastrointestinal absorption, and drug pharmacokinetics. I found the book to be an enjoyable and enlightening read. Professor Leslie Benet, Department of Bioengineering & Therapeutic Sciences, Schools of Pharmacy & Medicine, University of California, San Francisco, USA.
001454041 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed January 19, 2023).
001454041 650_0 $$aPharmacokinetics.
001454041 650_0 $$aDrugs$$xBioavailability.
001454041 650_0 $$aOral medication.
001454041 650_0 $$aDrugs$$xAbsorption and adsorption.
001454041 655_0 $$aElectronic books.
001454041 7001_ $$aTsekouras, Athanasios A.$$eauthor.
001454041 77608 $$iPrint version: $$z3031200241$$z9783031200243$$w(OCoLC)1346293253
001454041 852__ $$bebk
001454041 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-20025-0$$zOnline Access$$91397441.1
001454041 909CO $$ooai:library.usi.edu:1454041$$pGLOBAL_SET
001454041 980__ $$aBIB
001454041 980__ $$aEBOOK
001454041 982__ $$aEbook
001454041 983__ $$aOnline
001454041 994__ $$a92$$bISE