Prions and diseases / Wen-Quan Zou, Pierluigi Gambetti, editors.
Zou, Wen-Quan, editor.; Gambetti, Pierluigi, editor.
2023
QR502
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Title Prions and diseases / Wen-Quan Zou, Pierluigi Gambetti, editors.
Edition Second edition.
ISBN 9783031205651 (electronic bk.)
3031205650 (electronic bk.)
9783031205644
DOI https://doi.org/10.1007/978-3-031-20565-1
Published Cham, Switzerland : Springer, 2023.
Language English
Description 1 online resource (xii, 793 pages) : illustrations (some color)
Item Number 10.1007/978-3-031-20565-1 doi
Call Number QR502
Dewey Decimal Classification 579.2/9
Summary Transmissible spongiform encephalopathies (TSE), now known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains the most authoritative views about the past, present, and future of prions and prion diseases covering fresh perspectives on important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.
Note Includes index.
Bibliography, etc. Note References
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed January 19, 2023).
Added Author Zou, Wen-Quan, editor.
Gambetti, Pierluigi, editor.
Available in Other Form Prions and Diseases
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Record Appears in Online Resources > Ebooks
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Part I: HISTORY
Chapter 1: Transmissible Spongiform Encephalopathy: from its beginnings to Daniel Carleton Gajdusek
Part II: GENERAL ASPECTS OF PRIONS
Chapter 2: The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein
Chapter 3: Mammalian Prion Structures
Chapter 4: Insoluble Cellular Prion Protein and Other Neurodegeneration-related Misfolded Protein Aggregates in the Brain of Asymptomatic Individuals
Part III: CONVERSION AND STRAIN OF PRIONS
Chapter 5: Prion Conversion and Deformed Templating
Chapter 6: Prion Strain Interference
Chapter 7: Molecular Mechanisms Encoding Strains of Prions and Prion-Like Misfolded Proteins
Chapter 8: Cofactor Involvement in Prion Propagation
Chapter 9: Prion Protein Conversion and Lipids
Part IV: ENVIRONMENT AND TRANSMISSION OF PRIONS
Chapter 10: Prions in the Environment
Chapter 11: Environmentally Acquired Transmissible Spongiform Encephalopathy
Chapter 12: Risk of Transmission of Creutzfeldt-Jakob Disease by Blood Transfusion
Chapter 13: Species Barriers in Prion Disease
Part V: MODELLING OF PRIONS
Chapter 14: Modeling the Cell Biology of Prions
Chapter 15: Transgenic Mice Modelling in Prion Diseases
Chapter 16: Stem Cell Models in Prion Research
Chapter 17: Drosophila Models of Prion Diseases
Part VI: HUMAN PRION DISEASES AND OTHER PATHOLOGIES
Chapter 18: Human Sporadic Prion Diseases
Chapter 19 Genetic Creutzfeldt-Jakob and Gerstmann-Straussler-Scheinker Diseases
Chapter 20: Glycoform-selective Prions in Sporadic and Inherited Variably Protease-sensitive Prionopathies
Chapter 21: The Spectrum of Tau Pathology in Human Prion Disease
Chapter 22: Prion Protein Complex with mGluR5 Mediates Amyloid-Ç Synaptic Loss in Alzheimer's Disease
Chapter 23: Prion and Cancers
Chapter 24: Protective Role of Cellular Prion Protein in Tissue Ischemic/Reperfusion Injury
Part VII: ANIMAL PRION DISEASES
Chapter 25: Bovine Spongiform Encephalopathy
Chapter 26: Classical and Atypical Scrapie in Sheep and Goats
Chapter 27: Research models for studying chronic wasting disease
Part VIII: YEAST PRIONS
Chapter 28: Introduction to Yeast and Fungal Prions
Chapter 29: Yeast Prions Are Folded, In-Register Parallel Amyloids Subject to Multiple Anti-prion Systems
Part IX: DIAGNOSIS AND HUMAN PRION SURVEILLANCE
Chapter 30: Real-time quaking-induced conversion (QuIC) assays for the detection and diagnosis of human prion diseases
Chapter 31: Protein Misfolding Cyclic Amplification
Chapter 32: Skin Misfolded Proteins as Biomarkers for Diagnosis of Prion and Prion-like Diseases
Chapter 33: Diagnosis of Prion Disease: Conventional Approaches
Chapter 34: Human Prion Disease Surveillance
Part X: TREATMENT
Chapter 35: Overview on Treatment of Prion Diseases and Decontamination of Prions
Chapter 36: Gene Therapy Strategies for Prophylactic and Therapeutic Treatments of Human Prion Diseases
Chapter 37: Immunomodulation.

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