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Part Background. Fatigue a phenomenon of modern age? On the history of fatigue
Definitions, Epidemiology and etiological factors
Pathophysiology and differentiation to other symptoms and diseases
Immunopathology and pathogenesis
Part Clinic. Motor fatigue and fatigability in MS
Cognitive fatigue
Personality factors and motivation
Fatigue and depression
Sleep-wake disorders
Part Diagnostics. Clinical assessment instruments of fatigue
Imaging methods and fatigue
Electrophysiology and fatigue
Expert opinion and sociomedical evaluation
Part Therapy. Disease modifying drugs and fatigue
Symptomatic pharmacotherapy and fatigue
Non-pharmacological treatment and neurorehabilitation.

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