001454432 000__ 04250cam\a2200469\i\4500
001454432 001__ 1454432
001454432 003__ OCoLC
001454432 005__ 20230314003519.0
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001454432 007__ cr\cn\nnnunnun
001454432 008__ 230207s2023\\\\sz\a\\\\ob\\\\001\0\eng\d
001454432 020__ $$a9783030973933$$q(electronic bk.)
001454432 020__ $$a303097393X$$q(electronic bk.)
001454432 020__ $$z9783030973926
001454432 0247_ $$a10.1007/978-3-030-97393-3$$2doi
001454432 035__ $$aSP(OCoLC)1369068629
001454432 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dEBLCP
001454432 049__ $$aISEA
001454432 050_4 $$aRC262
001454432 08204 $$a616.99/4$$223/eng/20230207
001454432 1001_ $$aTarin, David,$$eauthor.
001454432 24510 $$aUnderstanding cancer :$$bthe molecular mechanisms, biology, pathology and clinical implications of malignant neoplasia /$$cDavid Tarin.
001454432 264_1 $$aCham :$$bSpringer,$$c[2023]
001454432 264_4 $$c©2023
001454432 300__ $$a1 online resource (xxv, 325 pages) :$$billustrations (chiefly color)
001454432 336__ $$atext$$btxt$$2rdacontent
001454432 337__ $$acomputer$$bc$$2rdamedia
001454432 338__ $$aonline resource$$bcr$$2rdacarrier
001454432 504__ $$aIncludes bibliographical references and index.
001454432 5050_ $$aUnderstanding the Nature of Cancer- General Principles -- The Phenomenon of Inappropriate Gene Expression and its Biological and Clinical Consequences -- The Tumour System -- The Host Stroma and the Tumour Microenvironment.
001454432 506__ $$aAccess limited to authorized users.
001454432 520__ $$aThis book provides a unique, wide-ranging description of the phenomenon of cancer and its pathological effects in diverse species including humans, domesticated and wild animals, invertebrates, and plants. The broad scope of information presented is used to construct radical new insights into biological self-regulation and explain their relevance to its disruption by cancerous growth and spread within the human body. Mechanisms of action of carcinogenic agents, initiation, progression, metastasis, inappropriate gene expression, dormancy, latency, regression, and reasons for susceptibility and/or resistance to cancer are all considered. Also discussed are criteria for pathological diagnosis, advances in treatment, implications for public health, and pitfalls in diagnosis and interpretation of experimental results. The book describes operational mechanisms of cancer at the levels of whole individual, organ, tissue, cell, molecular, and even atomic (quantum) scales of structural and physiological order. Evidence is assembled from all these levels of organization to show that cancer is a dynamically changing disorder and that it is an inherent and perpetual risk of multicellular composition. This provides pragmatic new biological and clinical perspectives on malignant neoplasia. The biological insight is that it is a consequence of progressing miscommunication within a cellular society. The clinical perspective is realistic but optimistic in reasoning that, although cancer can never be completely eradicated from human life, because it is a disorder of our intrinsic biological constitution, it can be controlled and ameliorated and even cured in a proportion of individuals. The text is profusely illustrated with over 300 macroscopic and microscopic pictures. It will stimulate curiosity and interest specialists, as well as beginners, in many scientific disciplines and provides copious references to the medical and scientific literature supporting its conclusions. Readers from fields as diverse as medicine, pathology, veterinary sciences, cell biology, molecular biology, developmental biology, and epidemiology will find the information the book contains thought-provoking, interesting, and useful. Additionally, specialists in occupational and environmental health and legal experts focusing on exposure to carcinogenic materials and pollution will find the contents valuable and informative.
001454432 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed February 7, 2023).
001454432 650_0 $$aCancer.
001454432 650_0 $$aOncology.
001454432 655_0 $$aElectronic books.
001454432 852__ $$bebk
001454432 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-030-97393-3$$zOnline Access$$91397441.1
001454432 909CO $$ooai:library.usi.edu:1454432$$pGLOBAL_SET
001454432 980__ $$aBIB
001454432 980__ $$aEBOOK
001454432 982__ $$aEbook
001454432 983__ $$aOnline
001454432 994__ $$a92$$bISE