Intro
Preface
Contents
Editors and Contributors
Chapter 1: Drug Repurposing: An Advance Way to Traditional Drug Discovery
1.1 Introduction
1.2 Rationale of Drug Repurposing
1.3 Role of Drug Repurposing in Conventional Pharmaceutical Market
1.4 Roadmap to Modern Drug Repurposing
1.5 Drug Repurposing Strategies and Approaches
1.5.1 Computational Approaches
1.5.2 Experimental Approaches
1.6 Opportunity and Challenges in Drug Repurposing
1.7 Conclusion
References
Chapter 2: Drug Polypharmacology Toward Drug Repurposing
2.1 Drug Pharmacology

2.2 Drug Repurposing
2.3 Need for Drug Repurposing
2.4 Challenges of Drug Repurposing
2.5 Different Strategies of Drug Repurposing
2.6 Methodology for Drug Repurposing
2.6.1 Virtual Screening
2.6.2 Structure Prediction of Target
2.7 Chemical Composition of Drug
2.8 Prediction of Protein Binding Site
2.9 Successful Example of Drug Repurposing
References
Chapter 3: Pharmacovigilance-Based Drug Repurposing
3.1 Drug Development and Pharmacovigilance
3.1.1 Need for Pharmacovigilance
3.2 Pharmacovigilance and Drug Repurposing
3.2.1 Serendipity

3.2.2 Signature Matching
3.2.3 Mechanistic Profiling
3.2.4 Inverse Signals
3.2.4.1 Signal
3.2.4.1.1 Inverse Signal
3.3 The Process of Drug Repurposing
3.3.1 Present Scenario
3.3.1.1 Alzheimerś Disease
3.3.1.2 Raynaudś Phenomenon (RP)
3.3.1.3 COVID-19
3.4 Future Perspectives
Further Reading
Chapter 4: In Silico Analysis of Cellular Interactors of PQBP1 for Potential Drug Repurposing
4.1 Introduction
4.2 Material and Methods
4.3 Results and Discussion
References
Chapter 5: Drug Repurposing Opportunities in Cancer
5.1 Introduction

5.2 Drug Repurposing
5.3 Drug Repurposing Barriers
5.4 Computational Approaches in Drug Repurposing
5.5 Drug Repurposing in Cancer
5.5.1 Importance of Drug Repurposing in Cancer Treatment
5.5.2 Repurposing Small-Molecule Non-Oncology Drugs
5.5.2.1 Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
5.5.2.1.1 Aspirin
5.5.2.1.2 Diclofenac
5.5.2.1.3 Ibuprofen
5.5.2.1.4 Naproxen
5.5.2.2 Statins
5.5.2.2.1 Simvastatin
5.5.2.3 Antidiabetic Drugs
5.5.2.3.1 Metformin
5.5.2.3.2 Phenformin
5.5.2.4 Selective Estrogen Receptor Modulators (SERMs)

5.5.2.4.1 Raloxifene
5.5.2.5 Antidepressants
5.5.2.5.1 Imipramine
5.5.2.5.2 Trifluoperazine
5.5.2.5.3 Fluoxetine
5.5.2.6 Antipsychotic
5.5.2.6.1 Chlorpromazine
5.5.2.7 Anticonvulsant
5.5.2.7.1 Valproic Acid
5.5.2.8 Antiviral Drugs
5.5.2.8.1 Ritonavir
5.5.2.8.2 Nelfinavir
5.5.2.8.3 Lopinavir
5.5.2.9 Antibiotics
5.5.2.9.1 Ciprofloxacin
5.5.2.9.2 Nifuroxazide
5.5.2.9.3 Moxifloxacin
5.5.2.10 Antifungals
5.5.2.10.1 Clotrimazole
5.5.2.10.2 Itraconazole
5.5.2.11 Antiepileptic Drug
5.5.2.11.1 Flunarizine
5.5.2.11.2 Prazosin