G protein-coupled receptors : immobilization and applications in drug discovery / Xinfeng Zhao, Qian Li, Jing Wang, Qi Liang, Jia Quan.
Zhao, Xinfeng, author.; Li, Qian, author.; Wang, Jing, author.; Liang, Qi, author.; Quan, Jia, author.
2023
QP552.G16
Available Online

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Title G protein-coupled receptors : immobilization and applications in drug discovery / Xinfeng Zhao, Qian Li, Jing Wang, Qi Liang, Jia Quan.
Author Zhao, Xinfeng, author.
ISBN 9789819900787 (electronic bk.)
9819900786 (electronic bk.)
9789819900770
9819900778
DOI https://doi.org/10.1007/978-981-99-0078-7
Published Singapore : Springer, 2023.
Language English
Description 1 online resource (91 pages) : illustrations (black and white, and color).
Other Standard Identifiers 10.1007/978-981-99-0078-7 doi
Call Number QP552.G16
Dewey Decimal Classification 572/.6
Summary This book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the post-structural biology era for G protein-coupled receptor research. As an emerging approach for state-of-the-art immobilization, this book discusses efforts to explore the elegance of naturally-occurring biochemical reactions by using their high specificity and robust reactivity in the complex system, such as site-specific conjugation by covalent recognition between enzymes and their substrates. With the perspective of protein-drug interactions, this book also reviews the applications of protein immobilization, with an emphasis on G protein-coupled receptors, in drug discovery and protein-ligand interaction analysis. In addition, the merits, opportunities and disadvantages are analyzed for different immobilization methods, and a perspective for future directions is presented. Given its scope, this book appeals to a broad readership, particularly researchers engaged in the field of analytical chemistry, bioconjugate chemistry, and chemical biology, and other related field, as well as teachers of relevant majors in colleges and universities.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Source of Description Description based on print version record.
Added Author Li, Qian, author.
Wang, Jing, author.
Liang, Qi, author.
Quan, Jia, author.
Series SpringerBriefs in molecular science.
Available in Other Form G protein-coupled receptors.
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
All Resources
G Protein-Coupled Receptors
Purification of G Protein-Coupled Receptors
Oriented Immobilization of G Protein-Coupled Receptors
Key Biochemical Aspects of Drug-Target Interactions
Immobilized GPCRs in Drug-Receptor Interaction Analysis
Immobilized GPCRs in Compound Screening.

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