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001461308 001__ 1461308
001461308 003__ OCoLC
001461308 005__ 20230503003346.0
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001461308 008__ 230316s2023\\\\sz\a\\\\o\\\\\000\0\eng\d
001461308 019__ $$a1372398604$$a1373232174
001461308 020__ $$a9783031224683$$q(electronic bk.)
001461308 020__ $$a303122468X$$q(electronic bk.)
001461308 020__ $$z9783031224676
001461308 020__ $$z3031224671
001461308 0247_ $$a10.1007/978-3-031-22468-3$$2doi
001461308 035__ $$aSP(OCoLC)1372392651
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001461308 049__ $$aISEA
001461308 050_4 $$aQP86
001461308 08204 $$a612.6/7$$223/eng/20230316
001461308 24500 $$aSleep and clocks in aging and longevity /$$cAnita Jagota, editor.
001461308 264_1 $$aCham :$$bSpringer,$$c[2023]
001461308 264_4 $$c©2023
001461308 300__ $$a1 online resource (ix, 561 pages) :$$billustrations (some color).
001461308 336__ $$atext$$btxt$$2rdacontent
001461308 337__ $$acomputer$$bc$$2rdamedia
001461308 338__ $$aonline resource$$bcr$$2rdacarrier
001461308 4901_ $$aHealthy ageing and longevity ;$$vvolume 18
001461308 5050_ $$aIntro -- Preface -- Contents -- Part I Understanding Sleep and Clock Interlink in Health and Longevity -- 1 Sleep and Circadian Clock: Novel Players in Health Impacts and Aging -- 1.1 Introduction -- 1.2 Sleep -- 1.2.1 What is Sleep? -- 1.2.2 Physiological Basis of Sleep -- 1.2.3 Types of Sleep/Different Stages of Sleep -- 1.2.4 Sleep Duration/Need -- 1.2.5 Regulation of Sleep -- 1.3 Biological Clock: Circadian Timing System (CTS) -- 1.3.1 SCN: Neurotransmitters in Input and Output Pathways -- 1.3.2 SCN: Relay Center for Information -- 1.3.3 Melatonin: Messenger of Darkness
001461308 5058_ $$a1.3.4 Molecular Components of CTS -- 1.4 Sleep and Circadian Rhythms: Interplay -- 1.4.1 The Two-Process Model: The Interaction of Circadian Forces and Sleep Homeostasis -- 1.4.2 Sleep Gate -- 1.5 Sleep and Clock Misalignment with Aging -- 1.5.1 Alterations in Sleep Structure in Old -- 1.5.2 Desynchronization of Circadian Rhythm Patterns in Old -- 1.5.3 The Circadian and Sleep Perturbances -- 1.6 Interventions to Improve Sleep and Clock Function: A Step Toward Healthy Aging and Longevity -- 1.6.1 Sleep Hygiene -- 1.6.2 Light Therapy -- 1.6.3 Administration of Exogenous Melatonin
001461308 5058_ $$a1.6.4 Herbal and Other Interventions -- 1.7 Goals and Conclusions -- References -- 2 Cells and Circuits of the Suprachiasmatic Nucleus and the Control of Circadian Behaviour and Sleep -- 2.1 Introduction: Mammalian Circadian System Overview -- 2.2 Molecular-Genetic and Cellular Basis of Circadian Timekeeping in Mammals -- 2.2.1 The Core Feedback Loop-Genes and Molecules: Discoveries Through Mapping and Mutagenesis Screens -- 2.2.2 Additional Feedback Loops Support the TTFL -- 2.2.3 Control of the Stability of Clock Proteins and Effect on Behaviour -- 2.3 Circadian Properties of SCN Neurons
001461308 5058_ $$a2.3.1 Observing Clock Proteins at the Cellular Level -- 2.3.2 SCN Neural Activity and Transcriptional Cycles -- 2.3.3 The Importance of Coupling Between SCN Neurons -- 2.4 Circuit Architecture of the SCN as a Neuronal Network -- 2.4.1 Entrainment of the SCN Network: Photic and Non-photic Cues -- 2.4.2 SCN Network Synchrony: GABA and Neuropeptides -- 2.4.3 VIP Axis: Mediator of SCN Photic Entrainment and Neuronal Synchrony -- 2.4.4 GRP Axis: An Accessory Entrainment and Synchronisation Pathway -- 2.4.5 AVP Axis: Within-Shell Coupling and Circadian Output
001461308 5058_ $$a2.4.6 Prokineticin-2 Axis: More Than an SCN Output? -- 2.4.7 An Emerging View of the Functional Topology of the SCN Network -- 2.5 The Role of Astrocytes in the SCN -- 2.5.1 Astrocytic Control of Circadian Rhythms -- 2.5.2 Astrocyte-To-Neuron-To-Astrocyte Communication Within the SCN Network -- 2.6 SCN Outputs and Control of Circadian Behaviour and Sleep -- 2.6.1 SCN Outputs and Control of Circadian Behaviour -- 2.6.2 SCN in the Circadian Regulation of Sleep -- 2.7 Conclusion and Future Perspectives -- References -- 3 Circadian Regulation of Sleep -- 3.1 Introduction
001461308 506__ $$aAccess limited to authorized users.
001461308 520__ $$aThis edited volume focuses on the interplay between sleep and circadian rhythms with health, aging and longevity. Sleep is absolutely important for human health and survival, as insufficient sleep is associated with a plethora of conditions, including the poor quality of life, onset of several diseases, and premature death. The sleepwake cycle is an evolutionary conserved neurobiological phenomenon, and is a prominent manifestation of the biological clocks localised in the suprachiasmatic nucleus (SCN). Understanding bidirectional relationship between sleep and circadian rhythms is of utmost importance and urgency, especially in the context of modern lifestyle where sleep is often out of phase with the internal body clocks, social jetlag, artificial lights and so on. The 25 chapters by leading researchers and experts from 11 countries are arranged into seven sections: understanding sleep and clock interlink in health and longevity; sleep, aging and longevity; clock, aging and longevity; melatonin, sleep and clock; genetic regulation of sleep and clock; therapeutic interventions in sleep disorders and clock misalignment; and experimental models to study sleep and clocks in aging and longevity. This book is useful for advanced undergraduate and graduate students, and researchers, educators, and other biomedical professionals. .
001461308 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed March 16, 2023).
001461308 650_0 $$aAging$$xPhysiological aspects.
001461308 650_0 $$aCircadian rhythms$$xHealth aspects.
001461308 655_0 $$aElectronic books.
001461308 7001_ $$aJagota, Anita,$$eeditor.
001461308 77608 $$iPrint version:$$z3031224671$$z9783031224676$$w(OCoLC)1349451323
001461308 830_0 $$aHealthy ageing and longevity ;$$vv. 18.
001461308 852__ $$bebk
001461308 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-22468-3$$zOnline Access$$91397441.1
001461308 909CO $$ooai:library.usi.edu:1461308$$pGLOBAL_SET
001461308 980__ $$aBIB
001461308 980__ $$aEBOOK
001461308 982__ $$aEbook
001461308 983__ $$aOnline
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